Low renin hypertensive states: perspectives, unsolved problems, future research

Gordon, R. D., Laragh, J. H. and Funder, J. W. (2005) Low renin hypertensive states: perspectives, unsolved problems, future research. Trends In Endocrinology And Metabolism, 16 3: 108-113. doi:10.1016/j.tem.2005.02.004


Author Gordon, R. D.
Laragh, J. H.
Funder, J. W.
Title Low renin hypertensive states: perspectives, unsolved problems, future research
Journal name Trends In Endocrinology And Metabolism   Check publisher's open access policy
ISSN 1043-2760
Publication date 2005-01-01
Year available 2005
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.tem.2005.02.004
Open Access Status
Volume 16
Issue 3
Start page 108
End page 113
Total pages 6
Place of publication United Kingdom
Publisher Elsevier
Language eng
Subject C1
321004 Endocrinology
730105 Endocrine organs and diseases (incl. diabetes)
1103 Clinical Sciences
Abstract Some causes of low renin hypertension are familial with known genetic bases. One of them, primary aldosteronism, is specifically treatable by mineralocorticoid receptor blockers or by surgery, and has at least two different familial varieties. These have provided insights into its natural history, with long normotensive and normokalemic phases, and variable expression within the same family. Primary aldosteronism was considered rare, but recent work beginning in 1992 suggests that it might be the most common curable cause of hypertension, worth screening for in every hypertensive. Evidence is now compelling that inappropriate aldosterone for salt status can cause not only hypertension, but vascular inflammation and end-organ damage, preventable by mineralocorticoid receptor blockade.
Keyword Endocrinology & Metabolism
Hyperaldosteronism Type-ii
Glucocorticoid-remediable Aldosteronism
Epithelial Sodium-channel
Primary-care
Curable Hypertension
Familial Variety
Liddles-syndrome
Angiotensin-ii
Beta-subunit
Ratio
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2006 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 15:30:47 EST