Contemporaneous fluctuations in T cell responses to persistent herpes virus infections

Crough, T, Burrows, JM, Fazou, C, Walker, S, Davenport, MP and Khanna, R (2005) Contemporaneous fluctuations in T cell responses to persistent herpes virus infections. European Journal of Immunology, 35 1: 139-149. doi:10.1002/eji.200425548

Author Crough, T
Burrows, JM
Fazou, C
Walker, S
Davenport, MP
Khanna, R
Title Contemporaneous fluctuations in T cell responses to persistent herpes virus infections
Journal name European Journal of Immunology   Check publisher's open access policy
ISSN 0014-2980
Publication date 2005-01-01
Sub-type Article (original research)
DOI 10.1002/eji.200425548
Volume 35
Issue 1
Start page 139
End page 149
Total pages 11
Editor L. L. Reth
Place of publication Weinheim, Germany
Publisher Wiley-VCH Verlag GmbH & Co. KGaA
Language eng
Subject C1
320202 Cellular Immunology
730101 Infectious diseases
Abstract The classical paradigm for T cell dynamics suggests that the resolution of a primary acute virus infection is followed by the generation of a long-lived pool of memory T cells that is thought to be highly stable. Very limited alteration in this repertoire is expected until the immune system is re-challenged by reactivation of latent viruses or by cross-reactive pathogens. Contradicting this view, we show here that the T cell repertoire specific for two different latent herpes viruses in the peripheral blood displayed significant contemporaneous co-fluctuations of virus-specific CD8(+) T cells. The coordinated responses to two different viruses suggest that the fluctuations within the T cell repertoire may be driven by sub-clinical viral reactivation or a more generalized 'bystander' effect. The later contention was supported by the observation that, while absolute number of CD3(+) T cells and their subsets and also the cell surface phenotype of antigen-specific T cells remained relatively constant, a loss of CD62L expression in the total CD8(+) T cell population was coincident with the expansion of tetramer-positive virus-specific T cells. This study demonstrates that the dynamic process of T cell expansion and contractions in persistent viral infections is not limited to the acute phase of infection, but also continues during the latent phase of infection.
Keyword Immunology
T Cells
Real-time Pcr
Homeostatic Proliferation
Cutting Edge
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2006 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 28 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 29 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 15:26:39 EST