Antiretrovirals as antimalarial agents

Skinner-Adams, Tina S., McCarthy, James S., Gardiner, Donald L., Hilton, Petrina M. and Andrews, Katherine T. (2004) Antiretrovirals as antimalarial agents. Journal of Infectious Diseases, 190 11: 1998-2000. doi:10.1086/425584

Author Skinner-Adams, Tina S.
McCarthy, James S.
Gardiner, Donald L.
Hilton, Petrina M.
Andrews, Katherine T.
Title Antiretrovirals as antimalarial agents
Journal name Journal of Infectious Diseases   Check publisher's open access policy
ISSN 0022-1899
Publication date 2004-12-01
Sub-type Article (original research)
DOI 10.1086/425584
Open Access Status
Volume 190
Issue 11
Start page 1998
End page 2000
Total pages 3
Editor M. S. Hirsch
Place of publication United States
Publisher Unviersity of Chicago Press
Language eng
Subject C1
321299 Public Health and Health Services not elsewhere classified
730212 Disease distribution and transmission
Abstract Recent studies have indicated that antiretroviral protease inhibitors may affect outcome in malarial disease. We have investigated the antimalarial activities of 6 commonly used antiretroviral agents. Our data indicate that, in addition to the previously published effects on cytoadherence and phagocytosis, the human immunodeficiency virus (HIV)-1 protease inhibitors saquinavir, ritonavir, and indinavir directly inhibit the growth of Plasmodium falciparum in vitro at clinically relevant concentrations. These findings are particularly important in light of both the high rate of malaria and HIV-1 coinfection in sub-Saharan Africa and the effort to employ highly active antiretroviral therapy in these regions.
Keyword Infectious Diseases
Immunodeficiency-virus Type-1
Plasmodium-falciparum Malaria
Q-Index Code C1

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Created: Wed, 15 Aug 2007, 15:20:17 EST