Transient prenatal vitamin D deficiency is associated with hyperlocomotion in adult rats

Burne, T. H. J., Becker, A., Brown, J., Eyles, D. W., MacKay-Sim, A. and McGrath, J. J. (2004) Transient prenatal vitamin D deficiency is associated with hyperlocomotion in adult rats. Behavioural Brain Research, 154 2: 549-555. doi:10.1016/j.bbr.2004.03.023

Author Burne, T. H. J.
Becker, A.
Brown, J.
Eyles, D. W.
MacKay-Sim, A.
McGrath, J. J.
Title Transient prenatal vitamin D deficiency is associated with hyperlocomotion in adult rats
Journal name Behavioural Brain Research   Check publisher's open access policy
ISSN 0166-4328
Publication date 2004-01-01
Year available 2004
Sub-type Article (original research)
DOI 10.1016/j.bbr.2004.03.023
Open Access Status Not yet assessed
Volume 154
Issue 2
Start page 549
End page 555
Total pages 7
Editor J. P. Huston
T. E. Robinson
Place of publication Netherlands
Publisher Elsevier BV
Language eng
Subject C1
321021 Psychiatry
730211 Mental health
Abstract Rat experiments have shown that prenatal Vitamin D deficiency leads to altered neonatal brain morphology, cell density and neurotrophin expression. In the current study we examined the hypothesis that Vitamin D deficiency during early development alters adult behaviour even when there is an intervening period in which the animal receives normal Vitamin D in later development. Rats were conceived and born to Vitamin D deficient dams (Birth); conceived, born and weaned from Vitamin D deficient dams (Weaning); or deficient in Vitamin D from conception to 10 weeks of age (Life). Litters were standardized to three males and three females per litter. All rat offspring were rendered normocalcaemic with calcium supplemented water (2 mM) after weaning. Control animals were born to mothers fed a normal diet but subject to similar litter size and calcium supplementation. At 10 weeks all animals were tested on the holeboard test, elevated plus maze test, social interaction observation, acoustic startle response test, prepulse inhibition of the acoustic startle response and a forced swim test. Early Vitamin D deficiency (Birth group) enhanced locomotion in the holeboard test and increased activity in the elevated plus maze. Thus, transient prenatal Vitamin D deficiency induces hyperlocomotion in adulthood, without severe motor abnormalities. (C) 2004 Elsevier B.V. All rights reserved.
Keyword Behavioral Sciences
Locomotor Activity
Elevated Plus Maze
Social Interaction
Swim Test
Acoustic Startle
Sprague-dawley Rats
Prepulse Inhibition
Vitamin D
Catch-up Growth
Prepulse Inhibition
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2005 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 90 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 15 Aug 2007, 15:15:59 EST