Combined prenatal and chronic postnatal vitamin D deficiency in rats impairs prepulse inhibition of acoustic startle

Burne, T. H. J., Feron, F., Brown, J., Eyles, D. W., McGrath, J. J. and Mackay-Sim, A. (2004) Combined prenatal and chronic postnatal vitamin D deficiency in rats impairs prepulse inhibition of acoustic startle. Physiology & Behavior, 81 4: 651-655. doi:10.1016/j.physbeh.2004.03.004


Author Burne, T. H. J.
Feron, F.
Brown, J.
Eyles, D. W.
McGrath, J. J.
Mackay-Sim, A.
Title Combined prenatal and chronic postnatal vitamin D deficiency in rats impairs prepulse inhibition of acoustic startle
Journal name Physiology & Behavior   Check publisher's open access policy
ISSN 0031-9384
Publication date 2004-01-01
Sub-type Article (original research)
DOI 10.1016/j.physbeh.2004.03.004
Volume 81
Issue 4
Start page 651
End page 655
Total pages 5
Editor J. M. Koolhass
S. C. Woods
Place of publication USA
Publisher Elsevier Inc
Collection year 2004
Language eng
Subject C1
321021 Psychiatry
730211 Mental health
Abstract There is growing evidence that 1,25-dihydroxyvitamin D-3 is involved in normal brain development. The aim of this study was to examine the impact of prenatal and postnatal hypovitaminosis D on prepulse inhibition (PPI) of acoustic startle in adult rats. We compared six groups of rats: control rats with normal vitamin D throughout life and normal litter size (Litter); control rats with normal vitamin D but with a reduced litter size of two (Control); offspring from reduced litters of vitamin D deplete mothers who were repleted at birth (Birth), repleted at weaning (Weaning) or remained on a deplete diet until 10 weeks of age (Life); or control rats that were placed on a vitamin D-deficient diet from 5 to 10 weeks of age (Adult). All rats were tested in acoustic startle chambers at 5 and 10 weeks of age for acoustic startle responses and for PPI. There were no significant group differences at 5 weeks of age on the acoustic startle response or on PPI. At 10 weeks of age, rats in the Life group only had impaired PPI despite having normal acoustic startle responses. We conclude that combined prenatal and chronic postnatal hypovitaminosis D, but not early life hypovitaminosis D, alters PPI. (C) 2004 Elsevier Inc. All rights reserved.
Keyword Behavioral Sciences
Psychology, Biological
Acoustic Startle
Development
Sprague-dawley Rats
Prepulse Inhibition
Animal-model
Schizophrenia
Neurons
Brain
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2005 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 15:15:53 EST