The role of the complement system in ischemia-reperfusion injury

Arumugam, Thiruma V., Shiels, Ian A., Woodruff, Trent M., Granger, D. Neil and Taylor, Stephen M. (2004) The role of the complement system in ischemia-reperfusion injury. Shock, 21 5: 401-409. doi:10.1097/01.shk.0000121227.73012.86

Author Arumugam, Thiruma V.
Shiels, Ian A.
Woodruff, Trent M.
Granger, D. Neil
Taylor, Stephen M.
Title The role of the complement system in ischemia-reperfusion injury
Journal name Shock   Check publisher's open access policy
ISSN 1073-2322
Publication date 2004-05-01
Year available 2004
Sub-type Article (original research)
DOI 10.1097/01.shk.0000121227.73012.86
Open Access Status Not yet assessed
Volume 21
Issue 5
Start page 401
End page 409
Total pages 9
Place of publication Augusta, GA. U.S.A.
Publisher Lippincott Williams & Wilkins
Language eng
Subject C1
320599 Pharmacology not elsewhere classified
730102 Immune system and allergy
1103 Clinical Sciences
Abstract Ischemia-reperfusion (I/R) injury is a common clinical event with the potential to seriously affect, and sometimes kill, the patient. Interruption of blood supply causes ischemia, which rapidly damages metabolically active tissues. Paradoxically, restoration of blood flow to the ischemic tissues initiates a cascade of pathology that leads to additional cell or tissue injury. I/R is a potent inducer of complement activation that results in the production of a number of inflammatory mediators. The use of specific inhibitors to block complement activation has been shown to prevent local tissue injury after I/R. Clinical and experimental studies in gut, kidney, limb, and liver have shown that I/R results in local activation of the complement system and leads to the production of the complement factors C3a, C5a, and the membrane attack complex. The novel inhibitors of complement products may find wide clinical application because there are no effective drug therapies currently available to treat I/R injuries.
Keyword Critical Care Medicine
Peripheral Vascular Disease
C5a Antagonist
Membrane Attack Complex
C5a Receptor Antagonist
Acute Myocardial-infarction
Remote Organ Injury
Human Polymorphonuclear Leukocytes
Lower Torso Ischemia
Rat Small-intestine
Ischemia/reperfusion Injury
Q-Index Code C1
Institutional Status UQ
Additional Notes This document is a journal review.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 210 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 216 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 15 Aug 2007, 14:55:00 EST