Lipid rafts and plasma membrane microorganization: insights from Ras

Parton, R. G. and Hancock, J. F. (2004) Lipid rafts and plasma membrane microorganization: insights from Ras. Trends In Cell Biology, 14 3: 141-147. doi:10.1016/j.tcb.2004.02.001


Author Parton, R. G.
Hancock, J. F.
Title Lipid rafts and plasma membrane microorganization: insights from Ras
Journal name Trends In Cell Biology   Check publisher's open access policy
ISSN 0962-8924
Publication date 2004-01-01
Year available 2004
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.tcb.2004.02.001
Open Access Status Not yet assessed
Volume 14
Issue 3
Start page 141
End page 147
Total pages 7
Place of publication London
Publisher Elsevier Ltd., Trends Journals
Language eng
Subject C1
270104 Membrane Biology
780106 Political science and public policy
Abstract The spatial organization of plasma membrane components in discrete microdomains is thought to be a key factor in the generation of distinct signal outputs. A detailed characterization of plasma membrane microdomains, including descriptions of their size, dynamics and abundance, has proved to be a taxing problem for cell biologists and biophysicists. The use of novel techniques is providing exciting new insights into the challenging problem of plasma membrane microstructure and has allowed the visualization of domains with the characteristics expected of lipid rafts - microdomains of the plasma membrane enriched in cholesterol and sphingolipids. This review focuses on some of these recent advances and uses Ras signaling as a paradigm for understanding inner plasma membrane organization and the role of lipid rafts in cellular function.
Keyword Cell Biology
Gpi-anchored Proteins
H-ras
Phosphoinositide 3-kinase
Cell-surface
K-ras
Model Membranes
Live Cells
Cholesterol
Caveolae
Microdomains
Q-Index Code C1
Grant ID GM66717
Institutional Status UQ
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2005 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 140 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 142 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 15 Aug 2007, 14:46:50 EST