Domains of the TGN: Coats, tethers and G proteins

Gleeson, Paul A., Lock, John G., Luke, Michael R. and Stow, Jennifer L. (2004) Domains of the TGN: Coats, tethers and G proteins. Traffic, 5 5: 315-326. doi:10.1111/j.1398-9219.2004.00182.x

Author Gleeson, Paul A.
Lock, John G.
Luke, Michael R.
Stow, Jennifer L.
Title Domains of the TGN: Coats, tethers and G proteins
Journal name Traffic   Check publisher's open access policy
ISSN 1398-9219
Publication date 2004-05-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1398-9219.2004.00182.x
Volume 5
Issue 5
Start page 315
End page 326
Total pages 12
Place of publication Denmark
Publisher John Wiley & Sons
Language eng
Subject C1
270103 Protein Targeting and Signal Transduction
780106 Political science and public policy
Abstract The trans-Golgi network is the major sorting compartment of the secretory pathway for protein, lipid and membrane traffic. There is a constant flow of membrane and cargo to and from this compartment. Evidence is emerging that the trans-Golgi network has multiple biochemically and functionally distinct subdomains, each of which contributes to the combined sorting and transport requirements of this dynamic compartment. The recruitment of distinct arrays of protein complexes to trans-Golgi network membranes is likely to produce the diversity of structure and biochemistry observed amongst subdomains that serve to generate different carriers or maintain resident trans-Golgi network components. This review discusses how these subdomains may be formed and examines the molecular players involved, including G proteins, clathrin adaptors and golgin tethers. Diversity within these protein families is highlighted and shown to be critical for the functionality of the trans-Golgi network, as a mediator of protein sorting and membrane transport, and for the maintenance of Golgi structure.
Keyword Cell Biology
Adp-ribosylation Factor
Grip Domain
Membrane Subdomains
Membrane Transport
Trans-golgi Network
Mannose 6-phosphate Receptors
Coiled-coil Proteins
Llc-pk1 Epithelial-cells
Ap-3 Adapter Complex
Distinct Membrane Domains
Clathrin Binding Subunit
Darby Canine Kidney
Ear Homology Domain
Q-Index Code C1
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2005 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 69 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 77 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 14:39:30 EST