Sox genes and cancer

Dong, C., Wilhelm, D. and Koopman, P. (2004) Sox genes and cancer. Cytogenetic and Genome Research, 105 2-4: 442-447. doi:10.1159/000078217


Author Dong, C.
Wilhelm, D.
Koopman, P.
Title Sox genes and cancer
Journal name Cytogenetic and Genome Research   Check publisher's open access policy
ISSN 1424-8581
Publication date 2004-01-01
Sub-type Article (original research)
DOI 10.1159/000078217
Volume 105
Issue 2-4
Start page 442
End page 447
Total pages 6
Place of publication Basal, Switzerland
Publisher Karger
Language eng
Subject C1
270205 Genetic Development (incl. Sex Determination)
780105 Biological sciences
Abstract Sox genes encode transcription factors belonging to the HMG ( High Mobility Group) superfamily. They are conserved across species and involved in a number of developmental processes. In vitro studies have shown at least one Sox gene to be capable of inducing oncogenic transformation of fibroblast cells. In addition, overexpression and/or amplification of Sox genes are associated with a large number of tumour types in vivo. We review here the available evidence linking Sox gene expression and cancer, and show that this link is supported by extensive EST database analysis. This work provides a basis for further studies aimed at investigating the possible role of Sox genes in the oncogenic process. Copyright (C) 2004 S. Karger AG, Basel.
Keyword Cell Biology
Genetics & Heredity
In-situ Hybridization
Sry-related Gene
Waardenburg-hirschsprung-disease
Autosomal Sex Reversal
Group Protein I(y)
Transcription Factor
Nucleoprotein Structures
Campomelic Dysplasia
Amplification Unit
Molecular Analysis
Q-Index Code C1
Additional Notes This article was published as a special issue of the journal Cytogenetic and Genome Research (Volume 105, No. 2-4, 2004). It has also been published as a reprint in Mouse genetics after the mouse genome, (S. Garagna, Ed.) Karger, Basel, 326pp. ISBN 3-8055-7783-4.

 
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Created: Wed, 15 Aug 2007, 14:34:34 EST