Routine changing of intravenous administration sets does not reduce colonization or infection in central venous catheters

Rickard, Claire M., Lipman, Jeff, Courtney, Mary, Siversen, Rosemary and Daley, Peter (2004) Routine changing of intravenous administration sets does not reduce colonization or infection in central venous catheters. Infection Control And Hospital Epidemiology, 25 8: 650-655. doi:10.1086/502456

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Author Rickard, Claire M.
Lipman, Jeff
Courtney, Mary
Siversen, Rosemary
Daley, Peter
Title Routine changing of intravenous administration sets does not reduce colonization or infection in central venous catheters
Journal name Infection Control And Hospital Epidemiology   Check publisher's open access policy
ISSN 0899-823X
Publication date 2004-08-01
Sub-type Article (original research)
DOI 10.1086/502456
Open Access Status File (Publisher version)
Volume 25
Issue 8
Start page 650
End page 655
Total pages 6
Place of publication New York, NY, United States
Publisher Cambridge University Press
Language eng
Formatted abstract
Objective:  To determine the effect of routine intravenous (IV) administration set changes on central venous catheter (CVC) colonization and catheter-related bacteremia.

Design:  Prospective, randomized, controlled trial.

Setting:  Eighteen-bed intensive care unit (ICU) in a large metropolitan hospital.

Participants:  Two hundred fifty-one patients with 404 chlorhexidine gluconate and silver sulfadiazine-coated multi-lumen CVCs.
Interventions:  CVCs inserted in the ICU and in situ on day 4 were randomized to have their IV administration sets changed on day 4 (n = 203) or not at all (n = 201). Use of fluid containers and blood product administration sets was limited to 24 hours. CVCs were removed when not required, infection was suspected, or in place on day 7. Catheter cultures were performed on removal by blinded laboratory staff. Catheter-related bacteremia was diagnosed by a blinded intensivist using strict definitions. Data were collected regarding catheter duration, site, Acute Physiology and Chronic Health Evaluation (APACHE) II score, patient age, diagnosis, hyperglycemia, hypoalbuminemia, immune status, number of fluid containers and IV injections, and administration of propofol, blood, total parenteral nutrition, or lipid infusion.

Results:  There were 10 colonized CVCs in the group receiving a set change and 19 in the group not receiving one. This difference was not statistically significant on Kaplan-Meier survival analysis. There were 3 cases of catheter-related bacteremia per group. Logistic regression found that burns diagnosis and increased ICU stay significantly predicted colonization.

Conclusion:  IV administration sets can be used for 7 days in patients with short-term, antiseptic-coated CVCs.
Keyword Public, Environmental & Occupational Health
Infectious Diseases
Blood-stream Infection
Infusion Fluid
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2005 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 21 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 14:29:05 EST