Bistability and switching in the lysis/lysogeny genetic regulatory network of bacteriophage lambda

Tian, TH and Burrage, K (2004) Bistability and switching in the lysis/lysogeny genetic regulatory network of bacteriophage lambda. Journal of Theoretical Biology, 227 2: 229-237. doi:10.1016/j.jtbi.2003.11.003


Author Tian, TH
Burrage, K
Title Bistability and switching in the lysis/lysogeny genetic regulatory network of bacteriophage lambda
Journal name Journal of Theoretical Biology   Check publisher's open access policy
ISSN 0022-5193
Publication date 2004-01-01
Sub-type Article (original research)
DOI 10.1016/j.jtbi.2003.11.003
Volume 227
Issue 2
Start page 229
End page 237
Total pages 9
Editor D. Kirschner
Y. Iwasa
L. Wolpert
Place of publication USA
Publisher Elsevier
Language eng
Subject C1
239901 Biological Mathematics
780105 Biological sciences
780101 Mathematical sciences
Abstract Bistability and switching are two important aspects of the genetic regulatory network of phage. Positive and negative feedbacks are key regulatory mechanisms in this network. By the introduction of threshold values, the developmental pathway of A phage is divided into different stages. If the protein level reaches a threshold value, positive or negative feedback will be effective and regulate the process of development. Using this regulatory mechanism, we present a quantitative model to realize bistability and switching of phage based on experimental data. This model gives descriptions of decisive mechanisms for different pathways in induction. A stochastic model is also introduced for describing statistical properties of switching in induction. A stochastic degradation rate is used to represent intrinsic noise in induction for switching the system from the lysogenic pathway to the lysis pathway. The approach in this paper represents an attempt to describe the regulatory mechanism in genetic regulatory network under the influence of intrinsic noise in the framework of continuous models. (C) 2003 Elsevier Ltd. All rights reserved.
Keyword Genetic Regulatory Networks
Stochastic Simulation
Bistability
Switching
Biology
Lambda Bacteriophage
Escherichia-coli
Right Operator
Repressor
Noise
Cro
Robustness
Expression
Model
Or3
Mathematical & Computational Biology
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 14:23:48 EST