Treatment of partial-thickness burns: A prospective, randomized trial using Transcyte (TM)

Kumar, Rohit J., Kimble, Roy M., Boots, Robert J. and Pegg, Stuart P. (2004) Treatment of partial-thickness burns: A prospective, randomized trial using Transcyte (TM). ANZ Journal of Surgery, 74 8: 622-626. doi:10.1111/j.1445-1433.2004.03106.x


Author Kumar, Rohit J.
Kimble, Roy M.
Boots, Robert J.
Pegg, Stuart P.
Title Treatment of partial-thickness burns: A prospective, randomized trial using Transcyte (TM)
Journal name ANZ Journal of Surgery   Check publisher's open access policy
ISSN 1445-1433
Publication date 2004-01-01
Year available 2004
Sub-type Article (original research)
DOI 10.1111/j.1445-1433.2004.03106.x
Open Access Status Not yet assessed
Volume 74
Issue 8
Start page 622
End page 626
Total pages 5
Editor R. J. S. Thomas
Place of publication Carlton South, Australia
Publisher Blackwell Publishing Asia
Language eng
Subject C1
321019 Paediatrics
730117 Skin and related disorders
Abstract Background: The purpose of the present study was to compare the effectiveness of three burns dressings (TransCyte, a bio-engineered skin substitute; Biobrane; and Silvazine cream (silver sulphadiazine and 0.2% chlorhexidine)), in treating children with partial-thickness burns. The primary objective was to determine the days until greater than or equal to90% re-epithelialization. The secondary objectives were to evaluate the number of wounds requiring autografting and the number of dressing changes/local wound care required. Methods: Study wounds were identified on each patient and the patients were randomized to receive TransCyte or Biobrane or Silvazine. Assessment of study wound closure began at 2 days after treatment and continued at least every other day thereafter until the wounds re-epithelialized or were autografted. A laser Doppler imaging system was used as an adjunct to assessing the depth of the burn. Results: Thirty-three patients with 58 wound sites enrolled in the study (TransCyte, n = 20, Biobrane, n = 17; Silvazine, n = 21). Mean time to re-epithelialization was 7.5 days for TransCyte, 9.5 days for Biobrane, and 11.2 days for Silvazine. The number of wounds requiring autografting were 5/21 (24%) for Silvazine, 3/17 (17%) for Biobrane, and 1/20 (5%) for TransCyte. Conclusions: When used in partial-thickness burns in children, TransCyte promotes fastest re-epithelialization and required less overall dressings then Biobrane or Silvazine. Patients who received Silvazine or Biobrane require more autografting than those treated with TransCyte.
Keyword Surgery
Biobrane
Partial-thickness Burns
Silvazine
Transcyte
Management
Anti-Infective Agents, Local/administration & dosage/*therapeutic use
Burns/*therapy
Child
Comparative Study
Drug Combinations
Follow-Up Studies
Occlusive Dressings
Skin Transplantation
Skin, Artificial
Skin Transplantation
Wound Healing/drug effects
Q-Index Code C1
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2005 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 14:22:54 EST