Ecotoxicity of ketoprofen, diclofenac, atenolol and their photolysis byproducts in zebrafish (Danio rerio)

Diniz, M. S., Salgado, R., Pereira, V. J., Carvalho, G., Oehmen, A., Reis, M. A. M. and Noronha, J. P. (2015) Ecotoxicity of ketoprofen, diclofenac, atenolol and their photolysis byproducts in zebrafish (Danio rerio). Science of the Total Environment, 505 282-289. doi:10.1016/j.scitotenv.014.09.103


Author Diniz, M. S.
Salgado, R.
Pereira, V. J.
Carvalho, G.
Oehmen, A.
Reis, M. A. M.
Noronha, J. P.
Title Ecotoxicity of ketoprofen, diclofenac, atenolol and their photolysis byproducts in zebrafish (Danio rerio)
Formatted title
Ecotoxicity of ketoprofen, diclofenac, atenolol and their photolysis byproducts in zebrafish (Danio rerio)
Journal name Science of the Total Environment   Check publisher's open access policy
ISSN 0048-9697
1879-1026
Publication date 2015-02-01
Sub-type Article (original research)
DOI 10.1016/j.scitotenv.014.09.103
Open Access Status Not yet assessed
Volume 505
Start page 282
End page 289
Total pages 8
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract The occurrence of pharmaceutical compounds in wastewater treatment plants and surface waters has been detected worldwide, constituting a potential risk for aquatic ecosystems. Adult zebrafish, of both sexes, were exposed to three common pharmaceutical compounds (atenolol, ketoprofen and diclofenac) and their UV photolysis by-products over seven days. The results show that diclofenac was removed to concentrations < LOD after 5 min of UV irradiation. The oxidative stress response of zebrafish to pharmaceuticals and their photolysis by-products was evaluated through oxidative stress enzymes (glutathione-S-transferase, catalase, superoxide dismutase) and lipid peroxidation. Results suggest that the photolysis by-products of diclofenac were more toxic than those from the other compounds tested, showing an increase in GST and CAT levels, which are also supported by higher MDA levels. Overall, the toxicity of waters containing atenolol and ketoprofen was reduced after the parent compounds were transformed by photolysis, whereas the toxicity increased significantly from the by-products generated through diclofenac photolysis. Therefore, diclofenac photolysis would possibly necessitate higher irradiation time to ensure that the associated by-products are completely degraded to harmless form(s).
Keyword Pharmaceuticals
Photolysis
By-products
Toxicity
Zebrafish
Oxidative stress
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemical Engineering Publications
 
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Created: Tue, 08 May 2018, 13:38:21 EST by Ms Kirsty Fraser on behalf of School of Chemical Engineering