The role of epigenetic changes in benzene-induced acute myeloid leukaemia

Peng, Cheng and Ng, Jack (2016) The role of epigenetic changes in benzene-induced acute myeloid leukaemia. Journal of Clinical Epigenetics, 2 2: . doi:10.21767/2472-1158.100019


Author Peng, Cheng
Ng, Jack
Title The role of epigenetic changes in benzene-induced acute myeloid leukaemia
Journal name Journal of Clinical Epigenetics
ISSN 2471-1158
Publication date 2016-05-17
Sub-type Critical review of research, literature review, critical commentary
DOI 10.21767/2472-1158.100019
Open Access Status DOI
Volume 2
Issue 2
Total pages 4
Place of publication London, United Kingdom
Publisher iMedPub LTD
Language eng
Abstract Acute myeloid leukaemia (AML) is a malignant cancer in blood and bone marrow with overall survival rate about 25% in adult. The main pathological changes of AML involve the dysfunctions of hematopoietic stem and progenitor cells including the abnormal proliferation, blocked differentiation and abolished apoptosis. Benzene is one of the widely used chemicals in petrol and an environmental leukaemogen that can cause AML and haematological malignancies. Although extensive research work has been conducted to investigate the health effects of benzene, the mechanisms behind the benzene-inducedleukaemogenesis remain unclear due to the complex toxicities of benzene. Genotoxic effects of the compound on hematopoietic system have been believed to be the main mechanism underlying benzene-induced leukaemogensis. Emerging evidences suggested that epigenetic modifications play an important role in the occurrence of diseases including AML. This review will summarize the recent studies based on literatures from Pubmed and discusses the role of epigenetics changes in Benzene-induced acute myeloid leukemia.
Keyword Myeloid leukaemia
Leukaemogen
Malignancies
Epigenetic
Genotoxic
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Queensland Alliance for Environmental Health Sciences (QAEHS) Publications
 
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Created: Sat, 05 May 2018, 17:29:30 EST by Dr Cheng Peng on behalf of UQ Centre for Clinical Research