Genetic epidemiology of migraine and depression

Yang, Yuanhao, Ligthart, Lannie, Terwindt, Gisela M., Boomsma, Dorret I., Rodriguez-Acevedo, Astrid J. and Nyholt, Dale R. (2016) Genetic epidemiology of migraine and depression. Cephalalgia, 36 7: 679-691. doi:10.1177/0333102416638520

Author Yang, Yuanhao
Ligthart, Lannie
Terwindt, Gisela M.
Boomsma, Dorret I.
Rodriguez-Acevedo, Astrid J.
Nyholt, Dale R.
Title Genetic epidemiology of migraine and depression
Journal name Cephalalgia   Check publisher's open access policy
ISSN 1468-2982
Publication date 2016-06-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1177/0333102416638520
Open Access Status Not yet assessed
Volume 36
Issue 7
Start page 679
End page 691
Total pages 13
Place of publication London, United Kingdom
Publisher Sage Publications
Language eng
Formatted abstract
Background: Migraine and major depressive disorder (commonly referred to as depression) are both common disorders with a significant impact on society. Studies in both clinical and community-based settings have demonstrated a strong relationship between migraine and depression. In addition to complicating the diagnosis, depression that is comorbid with migraine may lower treatment adherence, increase risk of medication overuse and is associated with migraine chronification, thus leading to higher direct and indirect costs and poorer health-related outcomes with increased disability.

Aim: The aim of this review is to summarise the current knowledge on the genetic epidemiology of migraine and depression and the possible biological mechanisms underlying their comorbidity. Methods We present a narrative review reporting on the current literature.

Results and conclusions: Epidemiological findings indicate that there is a bidirectional relationship between migraine and depression, with one disorder increasing the risk for the other and vice versa, suggesting shared biological mechanisms. Twin and family studies indicate that this bidirectional relationship can be explained, at least partly, by shared underlying genetically determined disease mechanisms. Although no genes have been robustly associated with the aetiology of both migraine and depression, genes from serotonergic, dopaminergic and GABAergic systems together with variants in the MTHFR and BDNF genes remain strong candidates.
Keyword Comorbid
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Institute for Molecular Bioscience - Publications
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Created: Fri, 20 Apr 2018, 12:21:28 EST