Jmjd6, a JmjC dioxygenase with many interaction partners and pleiotropic functions

Kwok, Janice, O'Shea, Marie, Hume, David A. and Lengeling, Andreas (2017) Jmjd6, a JmjC dioxygenase with many interaction partners and pleiotropic functions. Frontiers in Genetics, 8 . doi:10.3389/fgene.2017.00032


Author Kwok, Janice
O'Shea, Marie
Hume, David A.
Lengeling, Andreas
Title Jmjd6, a JmjC dioxygenase with many interaction partners and pleiotropic functions
Journal name Frontiers in Genetics   Check publisher's open access policy
ISSN 1664-8021
Publication date 2017-03-16
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3389/fgene.2017.00032
Open Access Status DOI
Volume 8
Total pages 19
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Language eng
Abstract Lysyl hydroxylation and arginyl demethylation are post-translational events that are important for many cellular processes. The jumonji domain containing protein 6 (JMJD6) has been reported to catalyze both lysyl hydroxylation and arginyl demethylation on diverse protein substrates. It also interacts directly with RNA. This review summarizes knowledge of JMJD6 functions that have emerged in the last 15 years and considers how a single Jumonji C (JmjC) domain-containing enzyme can target so many different substrates. New links and synergies between the three main proposed functions of Jmjd6 in histone demethylation, promoter proximal pause release of polymerase II and RNA splicing are discussed. The physiological context of the described molecular functions is considered and recently described novel roles for JMJD6 in cancer and immune biology are reviewed. The increased knowledge of JMJD6 functions has wider implications for our general understanding of the JmjC protein family of which JMJD6 is a member.
Keyword Chromatin
Demethylation
Hydroxylation
JmjC domain
Pausing
PSR
Splicing
Transcription
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Mater Research Institute-UQ (MRI-UQ)
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Created: Fri, 20 Apr 2018, 09:32:56 EST