Ribosomally-synthesised cyclic peptides from plants as drug leads and pharmaceutical scaffolds

Craik, David J., Lee, Meng-Han, Rehm, Fabian B.H., Tombling, Benjamin, Doffek, Benjamin and Peacock, Hayden (2017) Ribosomally-synthesised cyclic peptides from plants as drug leads and pharmaceutical scaffolds. Bioorganic and Medicinal Chemistry, . doi:10.1016/j.bmc.2017.08.005


Author Craik, David J.
Lee, Meng-Han
Rehm, Fabian B.H.
Tombling, Benjamin
Doffek, Benjamin
Peacock, Hayden
Title Ribosomally-synthesised cyclic peptides from plants as drug leads and pharmaceutical scaffolds
Journal name Bioorganic and Medicinal Chemistry   Check publisher's open access policy
ISSN 1464-3391
0968-0896
Publication date 2017-08-08
Sub-type Article (original research)
DOI 10.1016/j.bmc.2017.08.005
Open Access Status Not yet assessed
Total pages 11
Place of publication Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Subject 1303 Biochemistry
1313 Molecular Medicine
1312 Molecular Biology
3003 Pharmaceutical Science
3002 Drug Discovery
1308 Clinical Biochemistry
1605 Organic Chemistry
Abstract Owing to their exceptional stability and favourable pharmacokinetic properties, plant-derived cyclic peptides have recently attracted significant attention in the field of peptide-based drug design. This article describes the three major classes of ribosomally-synthesised plant peptides – the cyclotides, the PawS-derived peptides and the orbitides – and reviews their applications as leads or scaffolds in drug design. These ribosomally-produced peptides have a range of biological activities, including anti-HIV, cytotoxic and immunomodulatory activity. In addition, recent interest has focused on their use as scaffolds to stabilise bioactive peptide sequences, thereby enhancing their biopharmaceutical properties. There are now more than 30 published papers on such ‘grafting’ applications, most of which have been reported only in the last few years, and several such studies have reported in vivo activity of orally delivered cyclic peptides. In this article, we describe approaches to the synthesis of cyclic peptides and their pharmaceutically-grafted derivatives as well as outlining their biosynthetic routes. Finally, we describe possible bioproduction routes for pharmaceutically active cyclic peptides, involving plants and plant suspension cultures.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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Created: Fri, 13 Apr 2018, 10:10:40 EST