Consensus research priorities for paediatric status epilepticus: A Delphi study of health consumers, researchers and clinicians

Furyk, Jeremy, Ray, Robin, Watt, Kerriane, Dalziel, Stuart R., Oakely, Ed., Mackay, Mark, Dabscheck, Gabriel, Riney, Kate and Babl, Franz E. (2018) Consensus research priorities for paediatric status epilepticus: A Delphi study of health consumers, researchers and clinicians. Seizure, 56 104-109. doi:10.1016/j.seizure.2018.01.025


Author Furyk, Jeremy
Ray, Robin
Watt, Kerriane
Dalziel, Stuart R.
Oakely, Ed.
Mackay, Mark
Dabscheck, Gabriel
Riney, Kate
Babl, Franz E.
Title Consensus research priorities for paediatric status epilepticus: A Delphi study of health consumers, researchers and clinicians
Journal name Seizure   Check publisher's open access policy
ISSN 1532-2688
1059-1311
Publication date 2018-02-05
Sub-type Article (original research)
DOI 10.1016/j.seizure.2018.01.025
Open Access Status Not yet assessed
Volume 56
Start page 104
End page 109
Total pages 6
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Subject 2808 Neurology
2728 Clinical Neurology
Abstract Purpose: Status epilepticus (SE) is a paediatric emergency with significant morbidity and mortality. Recommendations beyond first line care are not based on high quality evidence. Emergency physicians and neurologists are key stakeholders in managing this condition. A collaborative, widely consulted approach to identifying priorities can help direct limited research funds appropriately. The objectives of this study are to identify consensus research priorities in paediatric SE among experts and health consumers. Methods: A three-stage Delphi process was conducted. Paediatric Neurologists and Emergency Physicians in Australia and New Zealand participated. Round one asked participants to generate three research questions important for further research in paediatric status epilepticus. Responses were refined into unique individual questions. Rounds two and three required participants to rate questions on a seven point ordinal scale. Health consumers were invited to participate by providing up to three problem areas that could be addressed by research. Results: 54 experts and 76 health consumers participated in the process. Nine questions reached our definition of consensus “high priority” 21 questions achieved consensus “low priority” and seven questions did not achieve consensus. High priority areas included second line management including levetiracetam (efficacy, dose and timing), use of third line agents, induction of anaesthesia (timing and best agent), management of focal SE, and indicators of “subtle SE”. Consumer priority areas included themes of treatment efficacy, aetiology, and community education. Conclusion: We identified nine priority research questions in paediatric SE, congruent with the health consumer theme of treatment efficacy. Future research efforts should be directed towards these priority areas.
Keyword Consensus
Paediatric
Seizures
Status epilepticus
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Fri, 13 Apr 2018, 09:46:55 EST