Balamuthia mandrillaris encephalitis: Survival of a child with severe meningoencephalitis and review of the literature

Moriarty, Paul, Burke, Christopher, McCrossin, David, Campbell, Robert, Cherian, Sarah, Shahab, Mohammad Shekeeb, Visvesvara, Govinda S. and Nourse, Clare (2013) Balamuthia mandrillaris encephalitis: Survival of a child with severe meningoencephalitis and review of the literature. Journal of the Pediatric Infectious Diseases Society, 3 1: 4-9. doi:10.1093/jpids/pit033


Author Moriarty, Paul
Burke, Christopher
McCrossin, David
Campbell, Robert
Cherian, Sarah
Shahab, Mohammad Shekeeb
Visvesvara, Govinda S.
Nourse, Clare
Title Balamuthia mandrillaris encephalitis: Survival of a child with severe meningoencephalitis and review of the literature
Journal name Journal of the Pediatric Infectious Diseases Society   Check publisher's open access policy
ISSN 2048-7207
2048-7193
Publication date 2013-07-03
Sub-type Article (original research)
DOI 10.1093/jpids/pit033
Open Access Status Not yet assessed
Volume 3
Issue 1
Start page 4
End page 9
Total pages 6
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Subject 2735 Pediatrics, Perinatology, and Child Health
2725 Infectious Diseases
Abstract Balamuthia mandrillaris causes granulomatous amoebic encephalitis, which is frequently fatal. There are few reports of survival in children. A 4-year-old child developed severe meningoencephalitis with multiple intracranial ring-enhancing lesions. Empiric therapy was commenced after a biopsy was performed, and the patient had a good clinical response. Molecular testing and indirect immunofluorescence later confirmed the diagnosis of Balamuthia encephalitis. Diagnosis of Balamuthia encephalitis is often delayed. The literature is reviewed with particular reference to reported survival. Prompt tissue diagnosis and initiation of therapy are common features among survivors. In previous reports, miltefosine was not used to treat children, but it was well tolerated in this case and should be considered as a therapeutic option.
Keyword Amoeba
Balamuthia
Encephalitis
Miltefosine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Medicine
 
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Created: Fri, 13 Apr 2018, 04:13:38 EST