Effect of omega-3 fatty acids supplementation during pregnancy on lung function in preschoolers: a clinical trial

Gutiérrez-Delgado, R. I., Barraza-Villarreal, A., Escamilla-Núñez, C., Hernández-Cadena, L., Garcia-Feregrino, R., Shackleton, C., Ramakrishnan, U., Sly, P. D. and Romieu, I. (2018) Effect of omega-3 fatty acids supplementation during pregnancy on lung function in preschoolers: a clinical trial. Journal of Asthma, 1-7. doi:10.1080/02770903.2018.1452934


Author Gutiérrez-Delgado, R. I.
Barraza-Villarreal, A.
Escamilla-Núñez, C.
Hernández-Cadena, L.
Garcia-Feregrino, R.
Shackleton, C.
Ramakrishnan, U.
Sly, P. D.
Romieu, I.
Title Effect of omega-3 fatty acids supplementation during pregnancy on lung function in preschoolers: a clinical trial
Journal name Journal of Asthma   Check publisher's open access policy
ISSN 1532-4303
0277-0903
Publication date 2018-04-04
Sub-type Article (original research)
DOI 10.1080/02770903.2018.1452934
Open Access Status Not yet assessed
Start page 1
End page 7
Total pages 7
Place of publication Philadelphia, PA, United States
Publisher Taylor & Francis
Language eng
Abstract Prenatal omega-3 fatty acids improve alveolarization, diminish inflammation, and improve pulmonary growth, but it is unclear whether these outcomes translate into improved postnatal lung function.

We assessed the effect of prenatal supplementation with docosahexaenoic acid (DHA) on offspring lung function through 60 months of age.

We included a cohort of 772 Mexican preschoolers whose mothers participated in a clinical trial (NCT00646360) of supplementation with DHA or a placebo from week 18-22 of gestation through delivery.

The children were followed after birth and anthropometric measurements and forced oscillation tests were performed at 36, 48, and 60 months of age. The effect of DHA was tested using a longitudinal mixed effect models.

Overall, mean (Standard Deviation) of the measurements of respiratory system resistance and respiratory system reactance at 6, 8, and 10 Hz during follow up period were 11.3 (2.4), 11.1 (2.4), 10.3 (2.2) and -5.2 (1.6), -4.8 (1.7), -4.6 (1.6), respectively. There were no significant differences in pulmonary function by treatment group. DHA did not affect the average lung function or the trajectories through 60 months.

Prenatal DHA supplementation did not influence pulmonary function in this cohort of Mexican preschoolers.
Formatted abstract
Rationale: Prenatal omega-3 fatty acids improve alveolarization, diminish inflammation, and improve pulmonary growth, but it is unclear whether these outcomes translate into improved postnatal lung function. Objective: We assessed the effect of prenatal supplementation with docosahexaenoic acid (DHA) on offspring lung function through 60 months of age.

Methods: We included a cohort of 772 Mexican preschoolers whose mothers participated in a clinical trial (NCT00646360) of supplementation with DHA or a placebo from week 18–22 of gestation through delivery.

Measurements: The children were followed after birth and anthropometric measurements and forced oscillation tests were performed at 36, 48, and 60 months of age. The effect of DHA was tested using a longitudinal mixed effect models.

Results: Overall, mean (Standard Deviation) of the measurements of respiratory system resistance and respiratory system reactance at 6, 8, and 10 Hz during follow up period were 11.3 (2.4), 11.1 (2.4), 10.3 (2.2) and –5.2 (1.6), –4.8 (1.7), –4.6 (1.6), respectively. There were no significant differences in pulmonary function by treatment group. DHA did not affect the average lung function or the trajectories through 60 months.

Conclusions: Prenatal DHA supplementation did not influence pulmonary function in this cohort of Mexican preschoolers.
Keyword Epidemiology
Mechanism
Pediatrics
Pregnancy
Prevention
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: eSpace Followup
Child Health Research Centre Publications
 
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Created: Wed, 11 Apr 2018, 10:06:51 EST