APP is required during an early phase of memory formation

Mileusnic, R, Lancashire, CL, Johnston, ANB and Rose, SPR (2000) APP is required during an early phase of memory formation. European Journal of Neuroscience, 12 12: 4487-4495. doi:10.1046/j.1460-9568.2000.01344.x

Author Mileusnic, R
Lancashire, CL
Johnston, ANB
Rose, SPR
Title APP is required during an early phase of memory formation
Journal name European Journal of Neuroscience   Check publisher's open access policy
ISSN 0953-816X
Publication date 2000-01-01
Year available 2000
Sub-type Article (original research)
DOI 10.1046/j.1460-9568.2000.01344.x
Volume 12
Issue 12
Start page 4487
End page 4495
Total pages 9
Place of publication OXFORD
Language eng
Abstract The amyloid beta /A4 protein precursor (APP) has been shown to be implicated in age-associated plastic changes at synapses that might contribute to memory loss in Alzheimer's disease. As APP has previously been reported to have multiple functions during normal development, we have employed a one-trial passive avoidance task in day-old chicks to study its role in the process of memory formation. Administration of anti-APR antibodies, injected 30 min pretraining, prevented memory for a one-trial passive avoidance task in day-old chicks without effects on general behaviour or initial acquisition. Amnesia was apparent by 30 min post-training acid lasted for at least 24 h. The same result was obtained by down-regulation of APP expression by APP-antisense, injected 8-12 h pretraining. However, injections of anti-APR antibodies or APP antisense at later post-training time did not cause amnesia for the task. Unlike antibodies and antisense, injection of the APP328-332 pentapeptide, in either orientation, 30 min pretraining, rescued the memory and prevented antisense-induced amnesia. The post-training time within which the antibody- and antisense-induced amnesia, and within which the APP peptides prevent amnesia, correspond to that during which memory formation is vulnerable to disruption of the putative signal transduction functions of APP. These results suggest that: (i) APP is required during an early phase of memory formation, and (ii) the memory enhancing effect of secretory APP is localized within a 5-mer sequence of growth-promoting domain.
Keyword β-amyloid precursor protein (βAPP)
APP antibody
APP antisense
APP328-332 peptides
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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