Olfactory dysfunction is associated with subjective memory complaints in community-dwelling elderly individuals

Sohrabi, Hamid R., Bates, Kristyn A., Rodrigues, Mark, Taddei, Kevin, Laws, Simon M., Lautenschlager, Nicola T., Dhaliwal, Satvinder S., Johnston, Amy N. B., Mackay-Sim, Alan, Gandy, Samuel, Foster, Jonathan K. and Martins, Ralph N. (2009) Olfactory dysfunction is associated with subjective memory complaints in community-dwelling elderly individuals. Journal of Alzheimers Disease, 17 1: 135-142. doi:10.3233/JAD-2009-1020

Author Sohrabi, Hamid R.
Bates, Kristyn A.
Rodrigues, Mark
Taddei, Kevin
Laws, Simon M.
Lautenschlager, Nicola T.
Dhaliwal, Satvinder S.
Johnston, Amy N. B.
Mackay-Sim, Alan
Gandy, Samuel
Foster, Jonathan K.
Martins, Ralph N.
Title Olfactory dysfunction is associated with subjective memory complaints in community-dwelling elderly individuals
Journal name Journal of Alzheimers Disease   Check publisher's open access policy
ISSN 1387-2877
Publication date 2009-01-01
Year available 2009
Sub-type Article (original research)
DOI 10.3233/JAD-2009-1020
Open Access Status Not yet assessed
Volume 17
Issue 1
Start page 135
End page 142
Total pages 8
Place of publication AMSTERDAM
Publisher IOS Press
Language eng
Abstract Olfactory dysfunction has been reported in clinical and preclinical phases of Alzheimer's disease. Subjective memory complaints have been proposed as a potential early indicator for increased risk of Alzheimer's disease, but have also been associated with depression, personality characteristics, and health problems. In this study, we aimed to determine which of these putative markers can predict memory complaints in community-dwelling elderly individuals, focusing on olfactory symptoms. A cohort of 144 elderly volunteers (42 males and 102 females), aged 50 to 86, was recruited from an ongoing longitudinal study. Participants were assessed for olfactory capacities (threshold, discrimination, and identification), subjective memory complaints, depression, and cognitive functions. Subjective memory complaints were significantly associated with olfactory discrimination and identification but not with threshold. Olfactory functions and depressive symptoms were both significantly associated with subjective memory complaints. In addition, memory complainers were significantly worse than non-complainers with respect to olfactory discrimination, identification, and overall olfactory functioning. The findings suggest that olfactory capacity may be a potentially significant biomarker for identifying community-dwelling elderly with memory complaints who are at increased risk for age-related cognitive decline and Alzheimer's disease.
Keyword Alzheimer's disease
Cognitive decline
Depression symptoms
Olfactory dysfunction
Smell identification
Sniffin' Sticks
Subjective memory complaints
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 52070400
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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