Role of brain-derived neurotrophic factor and presynaptic proteins in passive avoidance learning in day-old domestic chicks

Johnston, ANB, Clements, MP and Rose, SPR (1999) Role of brain-derived neurotrophic factor and presynaptic proteins in passive avoidance learning in day-old domestic chicks. Neuroscience, 88 4: 1033-1042. doi:10.1016/S0306-4522(98)00362-5


Author Johnston, ANB
Clements, MP
Rose, SPR
Title Role of brain-derived neurotrophic factor and presynaptic proteins in passive avoidance learning in day-old domestic chicks
Journal name Neuroscience   Check publisher's open access policy
ISSN 0306-4522
Publication date 1999-02-01
Year available 1999
Sub-type Article (original research)
DOI 10.1016/S0306-4522(98)00362-5
Volume 88
Issue 4
Start page 1033
End page 1042
Total pages 10
Place of publication OXFORD
Publisher PERGAMON-ELSEVIER SCIENCE LTD
Language eng
Abstract The consolidation of a one-trial passive avoidance learning task in the day-old chick involves a number of transient and longer-term biochemical processes, including increased release of glutamate. This study demonstrated that brain-derived neurotrophic factor, a proposed modulator of synaptic transmission and neurotransmitter release, is involved in the cascade associated with memory consolidation in the chick and that its actions were linked to modulation of expression of SNAP-25, syntaxin and synaptophysin, required for exocytosis. Intracerebral injections of 5 mu l of antibodies to brain-derived neurotrophic factor into the left and right intermediate medial hyperstriatum ventrale resulted in a dose-dependent reduction in avoidance of an "aversive" bead by 3 h after training. Neurotrophin antibodies (0.5 mu g/chick) administered between Ih before, and up to 30 min after, training induced amnesia by 3 h which was sustained for at least 24 h. Injections of recombinant brain-derived neurotrophic factor (50 mu g/ml; 0.5 mu g/chick) just before training maintained avoidance in birds trained with a weaker aversant (10% methylanthranilate), such that chicks showed enhanced recall at times (24 h) beyond that when shorter-term forms of memory have decayed. In lysed synaptosomal membranes prepared from chicks injected with antibodies to brain-derived neurotrophic factor there was a decrease in expression of SNAP-25 and syntaxin in the left, but not the right, intermediate medial hyperstriatum ventrale, a region known to be associated with memory formation, which correlated with the decrease in neurotrophin concentration.
Keyword BDNF
Memory
Neurotrophin
SNAP-25
Synaptophysin
Syntaxin
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: ResearcherID Downloads
Scopus Import
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 33 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 35 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 06 Apr 2018, 01:00:37 EST by Web Cron on behalf of Learning and Research Services (UQ Library)