Memory consolidation in day-old chicks requires BDNF but not NGF or NT-3; an antisense study

Johnston, ANB and Rose, SPR (2001) Memory consolidation in day-old chicks requires BDNF but not NGF or NT-3; an antisense study. Molecular Brain Research, 88 1-2: 26-36. doi:10.1016/S0169-328X(01)00016-X


Author Johnston, ANB
Rose, SPR
Title Memory consolidation in day-old chicks requires BDNF but not NGF or NT-3; an antisense study
Journal name Molecular Brain Research   Check publisher's open access policy
ISSN 0169-328X
Publication date 2001-03-01
Year available 2001
Sub-type Article (original research)
DOI 10.1016/S0169-328X(01)00016-X
Volume 88
Issue 1-2
Start page 26
End page 36
Total pages 11
Place of publication AMSTERDAM
Publisher ELSEVIER SCIENCE BV
Language eng
Abstract Neurotrophins have been implicated in memory consolidation and recall as well as in other forms of neural plasticity. This study examined the effects of Brain-Derived Neurotrophic Factor (BDNF), Nerve Growth Factor (NGF) and Neurotrophin-3 (NT-3) on consolidation of memory for a one-trial passive avoidance task in day-old chicks. In this task chicks, having pecked once at a bitter tasting bead, avoid a similar but dry bead subsequently. Intracerebral administration of antisense ODNs to BDNF 6-12 h prior to training induced amnesia for the avoidance response by 3 h after training. Administration of a 'control' scrambled sequence or saline had no effect on recall, chicks continued to avoid the bead. Treatment with BDNF-AS did not inhibit shorter-term recall; amnesia was not present 1 h after training, but prevented longer-term recall, as amnesia was still present 24 h after training. Treatment with BDNF-antisense reduced both BDNF mRNA and BDNF protein in the chick brain, but did not alter mRNA levels of glyceraldehyde-3-phosphate dehydrogenase. By contrast, no effect of antisense to NGF or NT-3 on behaviour was observed, even though administration reduced the mRNA for each. There were no significant effects of any antisense on other behavioural measures at the doses used. Thus we conclude that BDNF has a specific role in memory consolidation for the passive avoidance task. (C) 2001 Elsevier Science B.V. All rights reserved.
Keyword Antisense
Chicks
In situ hybridization
Learning and memory
Neurotrophins
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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Citation counts: TR Web of Science Citation Count  Cited 31 times in Thomson Reuters Web of Science Article | Citations
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