Antithrombotic Therapy in Nonvalvular Atrial Fibrillation: Consensus and Challenges

Khattak, Furqan, Alam, Mian B., Paul, Timir K., Rijal, Shasank, Wazir, Shoaib, Lavie, Carl J. and Saba, Samir (2018) Antithrombotic Therapy in Nonvalvular Atrial Fibrillation: Consensus and Challenges. American Journal of the Medical Sciences, . doi:10.1016/j.amjms.2018.01.013

Author Khattak, Furqan
Alam, Mian B.
Paul, Timir K.
Rijal, Shasank
Wazir, Shoaib
Lavie, Carl J.
Saba, Samir
Title Antithrombotic Therapy in Nonvalvular Atrial Fibrillation: Consensus and Challenges
Journal name American Journal of the Medical Sciences   Check publisher's open access policy
ISSN 1538-2990
Publication date 2018-01-01
Sub-type Article (original research)
DOI 10.1016/j.amjms.2018.01.013
Open Access Status Not yet assessed
Total pages 10
Place of publication Philadelphia, PA United States
Publisher Lippincott Williams & Wilkins
Language eng
Subject 2700 Medicine
Abstract Atrial fibrillation (AF) is associated with high risk of systemic thromboembolism leading to significant morbidity and mortality. Warfarin, previously the mainstay for stroke prevention in AF, requires close monitoring because of multiple food and drug interactions. In recent years, food and drug administration has approved several direct oral anticoagulants (DOACs) for use in patients with nonvalvular AF. These agents have not been studied in patients with valvular AF who are at an even higher risk of systemic thromboembolism. DOACs do not require frequent blood testing or changes in dosage except when renal function deteriorates, however, the lack of established antidotes for many of these agents remains a challenge. Also, currently there is no head-to-head comparison between these agents to guide clinical choice. This article discusses the advantages and disadvantages of currently approved oral antithrombotics in nonvalvular AF, with a special emphasis on the DOACs and their individual characteristics.
Keyword Antithrombotics
Atrial fibrillation
Direct oral anticoagulants
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Thu, 29 Mar 2018, 21:22:49 EST