Chicken anaemia virus evades host immune responses in transformed lymphocytes

Giotis, Efstathios S., Scott, Alistair, Rothwell, Lisa, Hu, Tuanjun, Talbot, Richard, Todd, Daniel, Burt, David W., Glass, Elizabeth J. and Kaiser, Pete (2018) Chicken anaemia virus evades host immune responses in transformed lymphocytes. Journal of General Virology, 99 3: 321-327. doi:10.1099/jgv.0.001011

Author Giotis, Efstathios S.
Scott, Alistair
Rothwell, Lisa
Hu, Tuanjun
Talbot, Richard
Todd, Daniel
Burt, David W.
Glass, Elizabeth J.
Kaiser, Pete
Title Chicken anaemia virus evades host immune responses in transformed lymphocytes
Journal name Journal of General Virology   Check publisher's open access policy
ISSN 1465-2099
Publication date 2018-03-01
Sub-type Article (original research)
DOI 10.1099/jgv.0.001011
Open Access Status Not yet assessed
Volume 99
Issue 3
Start page 321
End page 327
Total pages 7
Place of publication London, United Kingdom
Publisher Microbiology Society
Language eng
Subject 2406 Virology
Abstract Chicken anaemia virus (CAV) is a lymphotropic virus that causes anaemia and immunosuppression in chickens. Previously, we proposed that CAV evades host antiviral responses in vivo by disrupting T-cell signalling, but the precise cellular targets and modes of action remain elusive. In this study, we examined gene expression in Marek’s disease virus-transformed chicken T-cell line MSB-1 after infection with CAV using both a custom 5K immune-focused microarray and quantitative realtime PCR at 24, 48 and 72 h post-infection. The data demonstrate an intricate equilibrium between CAV and the host gene expression, displaying subtle but significant modulation of transcripts involved in the T-cell, inflammation and NF-kB signalling cascades. CAV efficiently blocked the induction of type-I interferons and interferon-stimulated genes at 72 h. The cell expression pattern implies that CAV subverts host antiviral responses and that the transformed environment of MSB-1 cells offers an opportunistic advantage for virus growth.
Keyword Chicken anaemia virus
Immune evasion
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Thu, 29 Mar 2018, 21:14:03 EST