Transcriptional regulation and macrophage differentiation

Hume, David A., Summers, Kim M. and Rehli, Michael (2016) Transcriptional regulation and macrophage differentiation. Microbiology Spectrum, 4 3: 1-19. doi:10.1128/microbiolspec.MCHD-0024-2015


Author Hume, David A.
Summers, Kim M.
Rehli, Michael
Title Transcriptional regulation and macrophage differentiation
Journal name Microbiology Spectrum   Check publisher's open access policy
ISSN 2165-0497
Publication date 2016-06-03
Sub-type Article (original research)
DOI 10.1128/microbiolspec.MCHD-0024-2015
Open Access Status Not yet assessed
Volume 4
Issue 3
Start page 1
End page 19
Total pages 19
Place of publication Washington, DC United States
Publisher American Society for Microbiology
Language eng
Subject 1314 Physiology
2303 Ecology
2400 Immunology and Microbiology
1311 Genetics
2726 Microbiology (medical)
1307 Cell Biology
2725 Infectious Diseases
Abstract Monocytes and macrophages are professional phagocytes that occupy specific niches in every tissue of the body. Their survival, proliferation, and differentiation are controlled by signals from the macrophage colony-stimulating factor receptor (CSF-1R) and its two ligands, CSF-1 and interleukin-34. In this review, we address the developmental and transcriptional relationships between hematopoietic progenitor cells, blood monocytes, and tissue macrophages as well as the distinctions from dendritic cells. A huge repertoire of receptors allows monocytes, tissue-resident macrophages, or pathology-associated macrophages to adapt to specific microenvironments. These processes create a broad spectrum of macrophages with different functions and individual effector capacities. The production of large transcriptomic data sets in mouse, human, and other species provides new insights into the mechanisms that underlie macrophage functional plasticity.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Medicine
 
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Created: Fri, 23 Mar 2018, 07:20:59 EST