Effects of volume resuscitation on the microcirculation in animal models of lipopolysaccharide sepsis: a systematic review

Obonyo, Nchafatso G., Fanning, Jonathon P., Ng, Angela S. Y., Pimenta, Leticia P., Shekar, Kiran, Platts, David G., Maitland, Kathryn and Fraser, John F. (2016) Effects of volume resuscitation on the microcirculation in animal models of lipopolysaccharide sepsis: a systematic review. Intensive Care Medicine Experimental, 4 1: 1-16. doi:10.1186/s40635-016-0112-3


Author Obonyo, Nchafatso G.
Fanning, Jonathon P.
Ng, Angela S. Y.
Pimenta, Leticia P.
Shekar, Kiran
Platts, David G.
Maitland, Kathryn
Fraser, John F.
Title Effects of volume resuscitation on the microcirculation in animal models of lipopolysaccharide sepsis: a systematic review
Journal name Intensive Care Medicine Experimental   Check publisher's open access policy
ISSN 2197-425X
Publication date 2016-02-21
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/s40635-016-0112-3
Open Access Status DOI
Volume 4
Issue 1
Start page 1
End page 16
Total pages 16
Place of publication Heidelberg, Germany
Publisher SpringerOpen
Language eng
Subject 2706 Critical Care and Intensive Care Medicine
Abstract Background: Recent research has identified an increased rate of mortality associated with fluid bolus therapy for severe sepsis and septic shock, but the mechanisms are still not well understood. Fluid resuscitation therapy administered for sepsis and septic shock targets restoration of the macro-circulation, but the pathogenesis of sepsis is complex and includes microcirculatory dysfunction. Objective: The objective of the study is to systematically review data comparing the effects of different types of fluid resuscitation on the microcirculation in clinically relevant animal models of lipopolysaccharide-induced sepsis. Methods: A structured search of PubMed/MEDLINE and EMBASE for relevant publications from 1 January 1990 to 31 December 2015 was performed, in accordance with PRISMA guidelines. Results: The number of published papers on sepsis and the microcirculation has increased steadily over the last 25�years. We identified 11 experimental animal studies comparing the effects of different fluid resuscitation regimens on the microcirculation. Heterogeneity precluded any meta-analysis. Conclusions: Few animal model studies have been published comparing the microcirculatory effects of different types of fluid resuscitation for sepsis and septic shock. Biologically relevant animal model studies remain necessary to enhance understanding regarding the mechanisms by which fluid resuscitation affects the microcirculation and to facilitate the transfer of basic science discoveries to clinical applications.
Keyword Fluid resuscitation
Intravital fluorescence microscopy
Laser Doppler flowmetry
Laser speckle imaging
Lipopolysaccharide
Microcirculation
Oxygen extraction
Sepsis
Septic shock
Sidestream dark-field videomicroscopy
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 100693
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 1 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 23 Mar 2018, 00:45:38 EST