Periodontitis and Rheumatoid Arthritis: A Review

Bartold, P M, Marshall, R I and Haynes, D R (2005) Periodontitis and Rheumatoid Arthritis: A Review. Journal of periodontology, 76 Suppl 11S 2066-2074. doi:10.1902/jop.2005.76.11-S.2066

Author Bartold, P M
Marshall, R I
Haynes, D R
Title Periodontitis and Rheumatoid Arthritis: A Review
Journal name Journal of periodontology   Check publisher's open access policy
ISSN 1943-3670
Publication date 2005-11-01
Sub-type Article (original research)
DOI 10.1902/jop.2005.76.11-S.2066
Open Access Status Not yet assessed
Volume 76 Suppl 11S
Start page 2066
End page 2074
Total pages 9
Abstract Periodontitis and rheumatoid arthritis (RA) appear to share many pathologic features. In this review, the common pathologic mechanisms of these two common chronic conditions are explored. Emerging evidence now suggests a strong relationship between the extent and severity of periodontal disease and RA. While this relationship is unlikely to be causal, it is clear that individuals with advanced RA are more likely to experience more significant periodontal problems compared to their non-RA counterparts, and vice versa. A case is made that these two diseases could be very closely related through common underlying dysfunction of fundamental inflammatory mechanisms. The nature of such dysfunction is still unknown. Nonetheless, there is accruing evidence to support the notion that both conditions manifest as a result of an imbalance between proinflammatory and anti-inflammatory cytokines. As a result, new treatment strategies are expected to emerge for both diseases that may target the inhibition of proinflammatory cytokines and destructive proteases. The clinical implications of the current data dictate that patients with RA should be carefully screened for their periodontal status.
Keyword Arthritis, rheumatoid
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Pubmed Import
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Citation counts: Scopus Citation Count Cited 166 times in Scopus Article | Citations
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Created: Wed, 21 Mar 2018, 10:05:57 EST