Treating cancer with microRNA replacement therapy: A literature review

Hosseinahli, Nayer, Aghapour, Mahyar, Duijf, Pascal H G and Baradaran, Behzad (2018) Treating cancer with microRNA replacement therapy: A literature review. Journal of Cellular Physiology, 233 8: 5574-5588. doi:10.1002/jcp.26514


Author Hosseinahli, Nayer
Aghapour, Mahyar
Duijf, Pascal H G
Baradaran, Behzad
Title Treating cancer with microRNA replacement therapy: A literature review
Journal name Journal of Cellular Physiology   Check publisher's open access policy
ISSN 1097-4652
0021-9541
Publication date 2018-03-09
Year available 2018
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/jcp.26514
Open Access Status Not yet assessed
Volume 233
Issue 8
Start page 5574
End page 5588
Total pages 15
Place of publication Hoboken, NJ., United States
Publisher John Wiley & Sons
Language eng
Subject 1314 Physiology
1308 Clinical Biochemistry
1307 Cell Biology
Abstract microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally by interfering with the translation of one or more target mRNAs. The unique miRNA sequences are involved in many physiological and pathological processes. Dysregulation of miRNAs contributes to the pathogenesis of all types of cancer. Notably, the diminished expression of tumor suppressor miRNAs, such as members of the Let-7 and miR-34 family, promotes tumor progression, invasion and metastasis. The past lustrum in particular, has witnessed substantial improvement of miRNA replacement therapy. This approach aims to restore tumor suppressor miRNA function in tumor cells using synthetic miRNA mimics or miRNA expression plasmids. Here, we provide a comprehensive review of recent advances in miRNA replacement therapy for treatment of cancer and its advantages over conventional gene therapy. We discuss a wide variety of delivery methods and vectors, as well as obstacles that remain to be overcome. Lastly, we review efforts to reverse epigenetic alterations, which affect miRNA expression in cancer cells, and the promising observation that restoring miRNA function re-sensitizes resistant tumor cells to chemotherapeutic drugs. The fact that various miRNA replacement therapies are currently in clinical trial demonstrates the great potential of this approach to treat cancer.
Keyword Cancer
MicroRNA
Replacement therapy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
UQ Diamantina Institute Publications
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Wed, 14 Mar 2018, 10:03:20 EST