Venomics-Accelerated Cone Snail Venom Peptide Discovery

Himaya, S W A and Lewis, Richard J (2018) Venomics-Accelerated Cone Snail Venom Peptide Discovery. International journal of molecular sciences, 19 3: . doi:10.3390/ijms19030788

Author Himaya, S W A
Lewis, Richard J
Title Venomics-Accelerated Cone Snail Venom Peptide Discovery
Journal name International journal of molecular sciences   Check publisher's open access policy
ISSN 1422-0067
Publication date 2018-03-09
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3390/ijms19030788
Open Access Status DOI
Volume 19
Issue 3
Abstract Cone snail venoms are considered a treasure trove of bioactive peptides. Despite over 800 species of cone snails being known, each producing over 1000 venom peptides, only about 150 unique venom peptides are structurally and functionally characterized. To overcome the limitations of the traditional low-throughput bio-discovery approaches, multi-omics systems approaches have been introduced to accelerate venom peptide discovery and characterisation. This "venomic" approach is starting to unravel the full complexity of cone snail venoms and to provide new insights into their biology and evolution. The main challenge for venomics is the effective integration of transcriptomics, proteomics, and pharmacological data and the efficient analysis of big datasets. Novel database search tools and visualisation techniques are now being introduced that facilitate data exploration, with ongoing advances in related omics fields being expected to further enhance venomics studies. Despite these challenges and future opportunities, cone snail venomics has already exponentially expanded the number of novel venom peptide sequences identified from the species investigated, although most novel conotoxins remain to be pharmacologically characterised. Therefore, efficient high-throughput peptide production systems and/or banks of miniaturized discovery assays are required to overcome this bottleneck and thus enhance cone snail venom bioprospecting and accelerate the identification of novel drug leads.
Keyword cone snails
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Pubmed Import
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Created: Wed, 14 Mar 2018, 10:03:15 EST