Factors related to nevus-associated cutaneous melanoma: a case-case study

Pandeya, Nirmala, Kvaskoff, Marina, Olsen, Catherine M, Green, Adèle C, Perry, Susan, Baxter, Catherine, Davis, Marcia B, Mortimore, Rohan, Westacott, Lorraine, Wood, Dominic, Triscott, Joe, Williamson, Richard and Whiteman, David C (2018) Factors related to nevus-associated cutaneous melanoma: a case-case study. The Journal of investigative dermatology, . doi:10.1016/j.jid.2017.12.036

Author Pandeya, Nirmala
Kvaskoff, Marina
Olsen, Catherine M
Green, Adèle C
Perry, Susan
Baxter, Catherine
Davis, Marcia B
Mortimore, Rohan
Westacott, Lorraine
Wood, Dominic
Triscott, Joe
Williamson, Richard
Whiteman, David C
Title Factors related to nevus-associated cutaneous melanoma: a case-case study
Journal name The Journal of investigative dermatology   Check publisher's open access policy
ISSN 1523-1747
Publication date 2018-03-07
Sub-type Article (original research)
DOI 10.1016/j.jid.2017.12.036
Abstract A proportion of cutaneous melanomas display neval remnants on histologic examination. Converging lines of epidemiologic and molecular evidence suggest that melanomas arising from nevus precursors differ from melanomas arising de novo. In a large, population-based study comprising 636 cutaneous melanomas subjected to dermatopathology review, we explored the molecular, host and environmental factors associated with the presence of neval remnants. We found nevus-associated melanomas were significantly associated with younger age at presentation, non-brown eye color, trunk site, thickness <0.5mm and BRAFmutation. Compared with patients with de novo melanomas, those with nevus-associated tumors were more likely to self-report many moles on their skin as a teenager (OR 1.94, 95% CI 1.01-3.72) but less likely to report many facial freckles (OR 0.49, 95% CI 0.25-0.96). They also had high total nevus counts (OR 2.18, 95% CI 1.26-3.78). On histologic examination, nevus-associated melanomas exhibited less dermal elastosis in adjacent skin compared with de novo melanomas (OR 0.55, 95% CI 0.30-1.01). These epidemiologic data accord with the emerging molecular paradigm that nevus-associated melanomas arise through a distinct sequence of causal events which differ from those leading to other cutaneous melanomas.
Keyword cutaneous melanoma
melanocytic nevus
neval remnants
sun exposure
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Pubmed Import
Version Filter Type
Citation counts: Google Scholar Search Google Scholar
Created: Wed, 14 Mar 2018, 10:02:30 EST