Complement in stem cells and development

Hawksworth, Owen A, Coulthard, Liam G, Mantovani, Susanna and Woodruff, Trent M (2018) Complement in stem cells and development. Seminars in immunology, . doi:10.1016/j.smim.2018.02.009

Author Hawksworth, Owen A
Coulthard, Liam G
Mantovani, Susanna
Woodruff, Trent M
Title Complement in stem cells and development
Journal name Seminars in immunology   Check publisher's open access policy
ISSN 1096-3618
Publication date 2018-03-07
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.smim.2018.02.009
Open Access Status Not yet assessed
Publisher Academic Press
Language eng
Subject 2723 Immunology and Allergy
2403 Immunology
Abstract From its discovery in the late nineteenth century, as a 'complement' to the cellular immune response, the complement system has been widely affirmed as a powerful controller of innate and adaptive immune responses. In recent decades however, new roles for complement have been discovered, with multiple complement proteins now known to function in a broad array of non-immune systems. This includes during development, where complement exerts control over stem cell populations from fertilization and implantation throughout embryogenesis and beyond post-natal development. It is involved in processes as diverse as cell localisation, tissue morphogenesis, and the growth and refinement of the brain. Such physiological actions of complement have also been described in adult stem cell populations, with roles in proliferation, differentiation, survival, and regeneration. With such a broad range of complement functions now described, it is likely that current research only describes a fraction of the full reach of complement proteins. Here, we review how complement control of physiological cell processes has been harnessed in stem cell populations throughout both development and in adult physiology.
Keyword Blastocyst
Complement activation
Progenitor cells
Stem cells
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Pubmed Import
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Created: Wed, 14 Mar 2018, 10:02:20 EST