Concentrations of organophosphate flame retardants and plasticizers in urine from young children in Queensland, Australia and associations with environmental and behavioural factors

He, Chang, English, Karin, Baduel, Christine, Thai, Phong, Jagals, Paul, Ware, Robert S., Li, Yan, Wang, Xianyu, Sly, Peter D. and Mueller, Jochen F. (2018) Concentrations of organophosphate flame retardants and plasticizers in urine from young children in Queensland, Australia and associations with environmental and behavioural factors. Environmental Research, 164 262-270. doi:10.1016/j.envres.2018.02.040


Author He, Chang
English, Karin
Baduel, Christine
Thai, Phong
Jagals, Paul
Ware, Robert S.
Li, Yan
Wang, Xianyu
Sly, Peter D.
Mueller, Jochen F.
Title Concentrations of organophosphate flame retardants and plasticizers in urine from young children in Queensland, Australia and associations with environmental and behavioural factors
Journal name Environmental Research   Check publisher's open access policy
ISSN 1096-0953
0013-9351
Publication date 2018-07-01
Sub-type Article (original research)
DOI 10.1016/j.envres.2018.02.040
Open Access Status Not yet assessed
Volume 164
Start page 262
End page 270
Total pages 9
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Language eng
Abstract In recent years, the production and usage volumes of organophosphate flame retardants (OPFRs) has increased substantially. Certain OPFRs are suspected reproductive toxins, carcinogenic, and neurotoxic. Insufficient information is available on human exposure pathways to these chemicals, particularly in Australia. We aim to assess the association between OPFR concentrations in the urine of children to environmental and behavioural risk factors. Concentrations of eight OPFRs and eleven metabolites were measured in the urine of 51 children, aged 3-29 months, in Southeast Queensland, Australia and compared to their behavioural and environmental risk factor data obtained by an online questionnaire. Of the 11 OPFR metabolites analysed, 55% were frequently detected in the majority (> 80%) of samples. The most frequently detected metabolite was bis(1,3-dichloroisopropyl) phosphate (BDCIPP) (detected in 100% of samples), followed by 1-hydroxy-2-propyl bis(1-chloro-2-propyl) phosphate (BCIPHIPP) (96%), diphenyl phosphate (DPHP) (94%) and bis(1-chloroisopropyl) phosphate (BCIPP) (86%). In multivariable modelling, age was positively associated with concentrations of bis(2-butoxyethyl) phosphate (BBOEP) and negatively associated with concentrations of BCIPP and BCIPHIPP. Other non-age related factors, including vacuuming frequency, hand-washing frequency and presence and number of some electrical appliances in the home were also associated with concentrations of OPFR metabolites.
Keyword Alternative flame retardants
Breastfeeding
Early exposure
Plasticizer
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Wed, 14 Mar 2018, 10:01:56 EST