Schistosome-induced fibrotic disease: The role of hepatic stellate cells

Carson, Jack P., Ramm, Grant A., Robinson, Mark W., McManus, Donald P. and Gobert, Geoffrey N. (2018) Schistosome-induced fibrotic disease: The role of hepatic stellate cells. Trends in Parasitology, . doi:10.1016/j.pt.2018.02.005


Author Carson, Jack P.
Ramm, Grant A.
Robinson, Mark W.
McManus, Donald P.
Gobert, Geoffrey N.
Title Schistosome-induced fibrotic disease: The role of hepatic stellate cells
Journal name Trends in Parasitology   Check publisher's open access policy
ISSN 1471-5007
1471-4922
Publication date 2018-03-08
Year available 2018
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.pt.2018.02.005
Open Access Status Not yet assessed
Total pages 17
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier
Language eng
Subject 2405 Parasitology
2725 Infectious Diseases
Abstract Hepatic fibrosis is a common pathology in various liver diseases. Hepatic stellate cells (HSCs) are the main cell type responsible for collagen deposition and fibrosis formation in the liver. Schistosomiasis is characterised by granulomatous fibrosis around parasite eggs trapped within the liver and other host tissues. This response is facilitated by the recruitment of immune cells and the activation of HSCs. The interactions between HSCs and schistosome eggs are complex and diverse, and a better understanding of these interactions could lead to improved resolution of fibrotic liver disease, including that associated with schistosomiasis. Here, we discuss recent advances in HSC biology and the role of HSCs in hepatic schistosomiasis.
Keyword Schistosoma
Collagen
Fibrosis
Hepatic stellate cell
Schistosomiasis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Faculty of Medicine
School of Clinical Medicine Publications
 
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Created: Wed, 14 Mar 2018, 10:01:44 EST