Topical interferon alpha-2b induced reactive lymphoid hyperplasia masquerading as orbital extension of ocular surface squamous neoplasia

Lee, Graham A., Hess, Lauren, Glasson, William J. and Whitehead, Kevin (2018) Topical interferon alpha-2b induced reactive lymphoid hyperplasia masquerading as orbital extension of ocular surface squamous neoplasia. Cornea, 37 6: 796-798. doi:10.1097/ICO.0000000000001547


Author Lee, Graham A.
Hess, Lauren
Glasson, William J.
Whitehead, Kevin
Title Topical interferon alpha-2b induced reactive lymphoid hyperplasia masquerading as orbital extension of ocular surface squamous neoplasia
Journal name Cornea   Check publisher's open access policy
ISSN 1536-4798
0277-3740
Publication date 2018-02-27
Year available 2018
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1097/ICO.0000000000001547
Open Access Status Not yet assessed
Volume 37
Issue 6
Start page 796
End page 798
Total pages 3
Place of publication Philadelphia, PA United States
Publisher Lippincott Williams & Wilkins
Abstract The use of topical interferon alpha-2b is a well-established treatment for ocular surface squamous neoplasia. There have been numerous reports on its efficacy and high safety profile. Benign reactive lymphoid hyperplasia in ocular tissues has not been previously documented by histopathology after interferon treatment.

This case report describes a 55-year-old man who had successful resolution of his ocular surface squamous neoplasia after topical treatment, but developed forniceal tissue deposits.

The appearance of the lesions was unexpected and alerted the clinician to the possibility of further neoplastic extension.

Excisional biopsy of the lesions confirmed benign reactive lymphoid hyperplasia and resolved with no recurrence.
Formatted abstract
Purpose: The use of topical interferon alpha-2b is a well-established treatment for ocular surface squamous neoplasia. There have been numerous reports on its efficacy and high safety profile. Benign reactive lymphoid hyperplasia in ocular tissues has not been previously documented by histopathology after interferon treatment.

Methods: This case report describes a 55-year-old man who had successful resolution of his ocular surface squamous neoplasia after topical treatment, but developed forniceal tissue deposits.

Results: The appearance of the lesions was unexpected and alerted the clinician to the possibility of further neoplastic extension.

Conclusions: Excisional biopsy of the lesions confirmed benign reactive lymphoid hyperplasia and resolved with no recurrence.
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collections: HERDC Pre-Audit
Faculty of Medicine
 
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Created: Wed, 07 Mar 2018, 11:06:40 EST