Effect of Ischemic Preconditioning on Lactate Accumulation and Running Performance

Bailey, Tom G., Jones, Helen, Gregson, Warren, Atkinson, Greg, Cable, Nigel Timothy and Thijssen, Dick H. J. (2012) Effect of Ischemic Preconditioning on Lactate Accumulation and Running Performance. Medicine and Science in Sports and Exercise, 44 11: 2084-2089. doi:10.1249/MSS.0b013e318262cb17

Author Bailey, Tom G.
Jones, Helen
Gregson, Warren
Atkinson, Greg
Cable, Nigel Timothy
Thijssen, Dick H. J.
Title Effect of Ischemic Preconditioning on Lactate Accumulation and Running Performance
Journal name Medicine and Science in Sports and Exercise   Check publisher's open access policy
ISSN 0195-9131
Publication date 2012-11-01
Year available 2012
Sub-type Article (original research)
DOI 10.1249/MSS.0b013e318262cb17
Open Access Status Not yet assessed
Volume 44
Issue 11
Start page 2084
End page 2089
Total pages 6
Place of publication Philadelphia, PA United States
Publisher Lippincott Williams & Wilkins
Language eng
Abstract BAILEY, T. G., H JONES, W. GREGSON, G. ATKINSON, N. T. CABLE, and D. H. J. THIJSSEN. Effect of Ischemic Preconditioning on Lactate Accumulation and Running Performance. Med. Set. Sports Exerc., Vol. 44, No. 11, pp. 2084-2089, 2012. Purpose: Repeated bouts of ischemia followed by reperfusion (i.e., ischemic preconditioning (IPC)) protect against damage after a myocardial infarction. Recent observational data indicate that IPC improves exercise performance. However, no previous study has examined potential underlying mechanisms for this effect of IPC. Therefore, we examined the potential of IPC to improve 5-km running time trial performance and reduce lactate accumulation during an incremental exercise test. Methods: In a randomized, crossover study, 13 healthy men performed running exercise, which was preceded by IPC (4 x 5-min 220 mm Hg bilateral leg occlusion) or a control intervention (C) (4 x 5-min 20 mm Hg bilateral leg occlusion). Participants performed a graded maximal treadmill running test, starting with five 3-min submaximal stages (10-14 km.h(-1)), followed by increments of 1 km.h(-1) every 2 min to 16 km.h(-1), followed by an incline of the treadmill of 2% every 2 min. Blood lactate was examined at each 3-min stage. After 45 min of rest in the supine position, subjects then performed a 5-km running time trial. Results: We found similar submaximal gas parameters during running exercise with both interventions. The overall increase in blood lactate during the submaximal stages was 1.07 +/- 0.11 mmol.L-1 lower when exercise was preceded with IPC versus C (P = 0.023). The 5-km running time trial was completed in a time that was 34 s faster after IPC versus C (95% confidence interval, 5-64 s; P = 0.027). Conclusion: IPC improves 5-km time trial performance in healthy male individuals. Moreover, we found that IPC is associated with an attenuated rise in blood lactate concentration at submaximal level during an incremental running test. This could indicate that IPC allows for higher work rates and thus improves time trial performance.
Keyword Time-Trial Performance
Incremental Exercise
Perceived Exertion
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 2009T064
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Human Movement and Nutrition Sciences Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 40 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 41 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 06 Mar 2018, 10:11:56 EST by Tom Bailey on behalf of Institute of Continuing & TESOL Education