The Long History of the Diverse Roles of Short ORFs: sPEPs in Fungi

Erpf, Paige E. and Fraser, James A. (2018) The Long History of the Diverse Roles of Short ORFs: sPEPs in Fungi. Proteomics, e1700219. doi:10.1002/pmic.201700219


Author Erpf, Paige E.
Fraser, James A.
Title The Long History of the Diverse Roles of Short ORFs: sPEPs in Fungi
Journal name Proteomics   Check publisher's open access policy
ISSN 1615-9861
1615-9853
Publication date 2018-02-21
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/pmic.201700219
Open Access Status Not yet assessed
Start page e1700219
Total pages 32
Place of publication Weinheim, Germany
Publisher Wiley - VCH Verlag
Abstract Since the completion of the genome sequence of the model eukaryote Saccharomyces cerevisiae there have been significant advancements in the field of genome annotation, in no small part due to the availability of datasets that make large-scale comparative analyses possible. As a result, since its completion there has been a significant change in annotated ORF size distribution in this first eukaryotic genome, especially in short ORFs (sORFs) predicted to encode polypeptides less than 150 amino acids in length. Due to their small size and the difficulties associated with their study, it is only relatively recently that these genomic features and the sORF-encoded peptides (sPEPs) they encode have become a focus of many researchers. Yet while this class of peptides may seem new and exciting, the study of this part of the proteome is nothing new in S. cerevisiae, a species where the biological importance of sPEPs has been elegantly illustrated over the past thirty years. Here we showcase a range of different sORFs found in S. cerevisiae and the diverse biological roles of their encoded sPEPs, and provide an insight into the sORFs found in other fungal species, particularly those pathogenic to humans. This article is protected by copyright. All rights reserved.
Keyword fungi
short ORF-encoded peptides
short ORFs
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
 
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Created: Wed, 28 Feb 2018, 11:06:57 EST