Mesoporous silica nanocarriers encapsulated antimalarials with high therapeutic performance

Amolegbe, Saliu Alao, Hirano, Yui, Adebayo, Joseph Oluwatope, Ademowo, Olusegun George, Balogun, Elizabeth Abidemi, Obaleye, Joshua Ayoola, Krettli, Antoniana Ursine, Yu, Chengzhong and Hayami, Shinya (2018) Mesoporous silica nanocarriers encapsulated antimalarials with high therapeutic performance. Scientific Reports, 8 1: 3078. doi:10.1038/s41598-018-21351-8

Author Amolegbe, Saliu Alao
Hirano, Yui
Adebayo, Joseph Oluwatope
Ademowo, Olusegun George
Balogun, Elizabeth Abidemi
Obaleye, Joshua Ayoola
Krettli, Antoniana Ursine
Yu, Chengzhong
Hayami, Shinya
Title Mesoporous silica nanocarriers encapsulated antimalarials with high therapeutic performance
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2018-02-15
Year available 2018
Sub-type Article (original research)
DOI 10.1038/s41598-018-21351-8
Open Access Status DOI
Volume 8
Issue 1
Start page 3078
Total pages 9
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract The use of nanocarriers in drug delivery is a breakeven research and has received a clarion call in biomedicine globally. Herein, two newly nano-biomaterials: MCM-41 encapsulated quinine (MCM-41 ⊃ QN) (1) and 3-phenylpropyl silane functionalized MCM-41 loaded QN (pMCM-41 ⊃ QN) (2) were synthesized and well characterized. 1 and 2 along with our two already reported nano-antimalarial drugs (MCM-41 ⊃ ATS) (3) and 3-aminopropyl silane functionalized MCM-41 contained ATS (aMCM-41 ⊃ ATS) (4) were screened in vitro for their activity against P. falciparium W2 strain, cytotoxicity against BGM cells and in vivo for their activity against Plasmodium bergheiNK65. 1 has the highest antimalarial activity in vivo against P. berghei NK65, (ED: < 0.0625 mg/kg body weight) and higher mean survival time compared to the other nano biomaterials or unencapsulated drugs at doses higher than 0.0625 mg/kg body weight. This encapsulation strategy of MCM-41 ⊃ QN (1) stands very useful and effective in delivering the drug to the target cells compared to other delivery systems and therefore, this encapsulated drug may be considered for rational drug design.
Keyword Water-Soluble Drugs
Oral Bioavailability
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID JP17H01200
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Australian Institute for Bioengineering and Nanotechnology Publications
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Created: Wed, 21 Feb 2018, 11:03:56 EST