Smokin` hot: adolescent smoking and the risk of psychosis

Mustonen, A., Ahokas, T., Nordström, T., Murray, G. K., Mäki, P., Jääskeläinen, E., Heiskala, A., Mcgrath, J. J., Scott, J. G., Miettunen, J. and Niemelä, S. (2018) Smokin` hot: adolescent smoking and the risk of psychosis. Acta psychiatrica Scandinavica, . doi:10.1111/acps.12863

Author Mustonen, A.
Ahokas, T.
Nordström, T.
Murray, G. K.
Mäki, P.
Jääskeläinen, E.
Heiskala, A.
Mcgrath, J. J.
Scott, J. G.
Miettunen, J.
Niemelä, S.
Title Smokin` hot: adolescent smoking and the risk of psychosis
Journal name Acta psychiatrica Scandinavica   Check publisher's open access policy
ISSN 1600-0447
Publication date 2018-02-18
Year available 2018
Sub-type Article (original research)
DOI 10.1111/acps.12863
Open Access Status Not yet assessed
Total pages 10
Place of publication Hoboken, NJ., United States
Publisher Wiley-Blackwell Publishing
Abstract Daily smoking has been associated with a greater risk of psychosis. However, we are still lacking studies to adjust for baseline psychotic experiences and other substance use. We examined associations between daily smoking and psychosis risk in a 15-year follow-up while accounting for these covariates in a prospective sample (N = 6081) from the Northern Finland Birth Cohort 1986.

Self-report questionnaires on psychotic experiences (PROD-screen), tobacco smoking and other substance use were completed when the cohort members were 15-16 years old. Tobacco smoking was categorized into three groups (non-smokers, 1-9 cigarettes and ≥10 cigarettes/day). Psychosis diagnoses were obtained from national registers until the age of 30 years.

Subjects in heaviest smoking category were at increased risk of subsequent psychosis (unadjusted HR = 3.15; 95% CI 1.94-5.13). When adjusted for baseline psychotic experiences the association persisted (HR = 2.87; 1.76-4.68) and remained significant even after adjustments for multiple known risk factors such as cannabis use, frequent alcohol use, other illicit substance use, parental substance abuse, and psychosis. Furthermore, number of smoked cigarettes increased psychosis risk in a dose-response manner (adjusted OR = 1.05; 1.01-1.08).

Heavy tobacco smoking in adolescence was associated with a greater risk for psychosis even after adjustment for confounders.
Keyword Epidemiology
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
HERDC Pre-Audit
Queensland Brain Institute Publications
Faculty of Medicine
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Created: Wed, 21 Feb 2018, 11:01:18 EST