PI3K-AKT-mTOR inhibition in cancer immunotherapy, redux

O'Donnell, Jake S., Massi, Daniela, Teng, Michele W. L. and Mandala, Mario (2017) PI3K-AKT-mTOR inhibition in cancer immunotherapy, redux. Seminars in Cancer Biology, 48 91-103. doi:10.1016/j.semcancer.2017.04.015

Author O'Donnell, Jake S.
Massi, Daniela
Teng, Michele W. L.
Mandala, Mario
Title PI3K-AKT-mTOR inhibition in cancer immunotherapy, redux
Journal name Seminars in Cancer Biology   Check publisher's open access policy
ISSN 1096-3650
Publication date 2017-05-01
Year available 2017
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.semcancer.2017.04.015
Open Access Status Not yet assessed
Volume 48
Start page 91
End page 103
Total pages 13
Place of publication London, United Kingdom
Publisher Academic Press
Language eng
Abstract Cancer therapies will increasingly be utilized in combination to treat advanced malignancies so as to increase their long-term efficacy in a greater proportion of patients. In particular, much attention has focused on developing targeted therapies that inhibit the PI3K-AKT-mTOR signaling network which is dysregulated in many cancer types. In addition, there is now a growing appreciation that targeting of these pathways can impact not only on cancer cells, but also host immunity. The clinical success of cancer immunotherapies targeting T-cell immune checkpoint receptors PD-1/PD-L1 has demonstrated the importance of immunoevasion as a hallmark of cancer. In this review, we discuss how PI3K-AKT-mTOR inhibitors target cancer cell biology, attenuate immune cell effector function and modulate the tumor microenvironment. We next discuss how the immunomodulatory potential of these inhibitors can be exploited through rational combinations with immunotherapies and targeted therapies.
Keyword AKT
Combination therapy
Immunotherapeutic resistance
Targeted therapy
Tumor microenvironment
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID PRIN 2015HAJH8E
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Medicine Publications
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Created: Wed, 14 Feb 2018, 12:58:09 EST