Using a simple equation to predict the microporation-enhanced transdermal drug flux

Rzhevskiy, Alexey S., Telaprolu, Krishna, Mohammed, Yousuf H., Grice, Jeffrey E., Roberts, Michael S. and Anissimov, Yuri G. (2018) Using a simple equation to predict the microporation-enhanced transdermal drug flux. European Journal of Pharmaceutics and Biopharmaceutics, 127 12-18. doi:10.1016/j.ejpb.2018.01.019


Author Rzhevskiy, Alexey S.
Telaprolu, Krishna
Mohammed, Yousuf H.
Grice, Jeffrey E.
Roberts, Michael S.
Anissimov, Yuri G.
Title Using a simple equation to predict the microporation-enhanced transdermal drug flux
Journal name European Journal of Pharmaceutics and Biopharmaceutics   Check publisher's open access policy
ISSN 1873-3441
0939-6411
Publication date 2018-02-01
Year available 2018
Sub-type Article (original research)
DOI 10.1016/j.ejpb.2018.01.019
Open Access Status Not yet assessed
Volume 127
Start page 12
End page 18
Total pages 7
Place of publication Amsterdam, NX Netherlands
Publisher Elsevier
Abstract The mathematical model describing drug flux through microporated skin was previously developed. Based on this model, two mathematical equations can be used to predict the microporatio-enhanced transdermal drug flux: the complex primal equation containing a variety of experimentally-determined variables, and the simplified straightforward equation. In this study, experimental transdermal fluxes of three corticosteroids through split-thickness human skin treated with a microneedle roller were measured, and the values of fluxes compared with those predicted using both the more complex and simplified equations. According to the results of the study, both equations demonstrated high accuracy in the prediction of the fluxes of corticosteroids. The simplified equation was validated and confirmed as robust using regression analysis of literature data. Further, its capability and ease of use was exemplified by predicting the flux of methotrexate through the skin microporated with laser and comparing with published experimental data.
Keyword Mathematical modelling
Microporation
Percutaneous penetration
Skin flux enhancement
Transdermal drug delivery
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
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Created: Wed, 14 Feb 2018, 11:09:27 EST