The placental immune response is dysregulated developmentally vitamin D deficient rats: Relevance to autism

Ali, Asad, Cui, Xiaoying, Alexander, Suzanne and Eyles, Darryl (2018) The placental immune response is dysregulated developmentally vitamin D deficient rats: Relevance to autism. The Journal of Steroid Biochemistry and Molecular Biology, . doi:10.1016/j.jsbmb.2018.01.015


Author Ali, Asad
Cui, Xiaoying
Alexander, Suzanne
Eyles, Darryl
Title The placental immune response is dysregulated developmentally vitamin D deficient rats: Relevance to autism
Journal name The Journal of Steroid Biochemistry and Molecular Biology   Check publisher's open access policy
ISSN 1879-1220
0960-0760
Publication date 2018-02-03
Year available 2018
Sub-type Article (original research)
DOI 10.1016/j.jsbmb.2018.01.015
Open Access Status Not yet assessed
Total pages 8
Place of publication Oxford, United Kingdom
Publisher Pergamon Press
Abstract Emerging evidence suggests that maternal or developmental vitamin D (DVD) deficiency is a risk factor for Autism Spectrum Disorders. A well-established association has also been found between gestational infection and increased incidence of autism. Placenta mediates the maternal immune response in respect to the foetus. The placenta is also a major source of vitamin D and locally produced vitamin D is an essential regulator of immune function during pregnancy. Here we investigate the effects of DVD-deficiency on baseline placental immune status and in response to the well-known viral and bacterial immune activating agents polyriboinosinic-polyribocytidylic acid (poly(I:C) and lipopolysaccharide (LPS). We show DVD-deficiency does not affect baseline inflammatory cytokines in placenta. However, when challenged with poly(I:C) but not LPS, DVD-deficient placentas from male foetuses had higher production of IL-6 and 1L-1β compared to control placentas. This suggests the developing DVD-deficient male foetus may be particularly vulnerable to maternal viral exposures. This in turn may have adverse implications for the developing male brain. In conclusion, a dysregulated placental immune response may provide a plausible mechanism for both the epidemiological links between DVD-deficiency and increased male incidence of developmental conditions such as autism.
Keyword Autism
DVD-deficiency
IL-1β
IL-6
Placenta
Poly(I:C)
Vitamin D
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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Created: Wed, 14 Feb 2018, 11:09:05 EST