Prolonged Uninterrupted Sitting Elevates Postprandial Hyperglycaemia Proportional to Degree of Insulin Resistance

Dempsey, Paddy C., Larsen, Robyn N., Winkler, Elisabeth A. H., Owen, Neville, Kingwell, Bronwyn A. and Dunstan, David W. (2018) Prolonged Uninterrupted Sitting Elevates Postprandial Hyperglycaemia Proportional to Degree of Insulin Resistance. Diabetes, Obesity and Metabolism, 20 6: 1526-1530. doi:10.1111/dom.13254


Author Dempsey, Paddy C.
Larsen, Robyn N.
Winkler, Elisabeth A. H.
Owen, Neville
Kingwell, Bronwyn A.
Dunstan, David W.
Title Prolonged Uninterrupted Sitting Elevates Postprandial Hyperglycaemia Proportional to Degree of Insulin Resistance
Journal name Diabetes, Obesity and Metabolism   Check publisher's open access policy
ISSN 1463-1326
1462-8902
Publication date 2018-03-06
Year available 2018
Sub-type Article (original research)
DOI 10.1111/dom.13254
Open Access Status Not yet assessed
Volume 20
Issue 6
Start page 1526
End page 1530
Total pages 5
Place of publication West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Subject 2724 Internal Medicine
2712 Endocrinology, Diabetes and Metabolism
1310 Endocrinology
Abstract Prolonged uninterrupted sitting is related adversely to cardiometabolic risk markers and postprandial hyperglycaemia, relative to sitting interrupted by regular brief activity breaks. However, whether the magnitude of hyperglycaemic responses to prolonged sitting is dependent upon the underlying degree of insulin resistance remains unclear. Data were pooled from three randomised cross-over laboratory-based trials (n=62) that examined the postprandial blood glucose- and insulin-lowering effects of prolonged sitting versus sitting interrupted by regular brief activity breaks in overweight/obese adults who had normal or impaired glucose metabolism (two trials), or type 2 diabetes not treated by insulin (one trial). Corrected for study effects, the magnitude of differences in postprandial glucose and insulin responses between the two conditions was significantly exacerbated with poorer baseline levels of fasting glucose, insulin and/or surrogate markers of β-cell function and insulin resistance. This suggests that those with higher underlying levels of insulin resistance may derive greater metabolic benefits from regularly interrupting prolonged sitting than their counterparts. If these findings can be replicated, they will have implications for future targeting and optimisation of physical activity/sedentary behaviour interventions in the prevention and management of type 2 diabetes.
Keyword diabetes
exercise
glycaemic control
insulin resistance
sedentary behaviour
sitting
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 540107
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Public Health Publications
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Wed, 14 Feb 2018, 11:01:54 EST