Early life Vitamin D depletion alters the postnatal response to skeletal loading in growing and mature bone

Borg, Stephanie A., Buckley, Harriet, Owen, Robert, Marin, Ana Campos, Lu, Yongtau, Eyles, Darryl, Lacroix, Damien, Reilly, Gwendolen C., Skerry, Tim M. and Bishop, Nick J. (2018) Early life Vitamin D depletion alters the postnatal response to skeletal loading in growing and mature bone. PLoS One, 13 1: . doi:10.1371/journal.pone.0190675


Author Borg, Stephanie A.
Buckley, Harriet
Owen, Robert
Marin, Ana Campos
Lu, Yongtau
Eyles, Darryl
Lacroix, Damien
Reilly, Gwendolen C.
Skerry, Tim M.
Bishop, Nick J.
Title Early life Vitamin D depletion alters the postnatal response to skeletal loading in growing and mature bone
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2018-01-01
Year available 2018
Sub-type Article (original research)
DOI 10.1371/journal.pone.0190675
Open Access Status DOI
Volume 13
Issue 1
Total pages 17
Place of publication San Francisco, CA., United States
Publisher Public Library of Science
Language eng
Subject 1300 Biochemistry, Genetics and Molecular Biology
1100 Agricultural and Biological Sciences
Abstract There is increasing evidence of persistent effects of early life vitamin D exposure on later skeletal health; linking low levels in early life to smaller bone size in childhood as well as increased fracture risk later in adulthood, independently of later vitamin D status. A major determinant of bone mass acquisition across all ages is mechanical loading. We tested the hypothesis in an animal model system that early life vitamin D depletion results in abrogation of the response to mechanical loading, with consequent reduction in bone size, mass and strength during both childhood and adulthood. A murine model was created in which pregnant dams were either vitamin D deficient or replete, and their offspring moved to a vitamin D replete diet at weaning. Tibias of the offspring were mechanically loaded and bone structure, extrinsic strength and growth measured both during growth and after skeletal maturity. Offspring of vitamin D deplete mice demonstrated lower bone mass in the non loaded limb and reduced bone mass accrual in response to loading in both the growing skeleton and after skeletal maturity. Early life vitamin D depletion led to reduced bone strength and altered bone biomechanical properties. These findings suggest early life vitamin D status may, in part, determine the propensity to osteoporosis and fracture that blights later life in many individuals.
Keyword Dried Blood Spots
D Deficiency
25-Hydroxyvitamin D
Heart-Disease
Cortical Bone
Fetal Bone
Male-Mice
Pregnancy
Mass
Adaptation
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID MR/ L002191/1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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Created: Fri, 09 Feb 2018, 02:49:47 EST