Cryoinjury model for tissue injury and repair in bioengineered human striated muscle

Mills, Richard J., Voges, Holly K., Porrello, Enzo R. and Hudson, James E. (2017). Cryoinjury model for tissue injury and repair in bioengineered human striated muscle. In Skeletal Muscle Development (pp. 209-224) New York, NY, United States: Humana Press. doi:10.1007/978-1-4939-7283-8_15


Author Mills, Richard J.
Voges, Holly K.
Porrello, Enzo R.
Hudson, James E.
Title of chapter Cryoinjury model for tissue injury and repair in bioengineered human striated muscle
Title of book Skeletal Muscle Development
Place of Publication New York, NY, United States
Publisher Humana Press
Publication Year 2017
Sub-type Research book chapter (original research)
DOI 10.1007/978-1-4939-7283-8_15
Open Access Status Not yet assessed
Series Methods in Molecular Biology
ISBN 9781493972821
9781493972838
ISSN 1064-3745
1940-6029
Volume number 1668
Chapter number 15
Start page 209
End page 224
Total pages 16
Total chapters 15
Language eng
Subjects 1312 Molecular Biology
1311 Genetics
Abstract/Summary Regenerative medicine aims to replace injured tissues to restore normal physiological function. One possibility for achieving this goal is to activate or enhance endogenous regenerative pathways. Therefore, human tissue regeneration models may be useful tools for the discovery and development of novel regenerative therapeutics. In this chapter, we describe methods for the generation of three-dimensional bioengineered striated muscle in vitro and a cryoinjury model that can be applied to these tissues. This technique enables mechanistic in vitro analysis of the endogenous regenerative response of human striated muscle to injury, which is not possible using other in vivo approaches.
Keyword Bioengineering
Cardiac muscle
Cryoinjury
Injury model
Regeneration
Skeletal muscle
Q-Index Code B1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Book Chapter
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School of Biomedical Sciences Publications
 
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Created: Fri, 09 Feb 2018, 01:47:43 EST