Perinatal tissue-derived endothelial progenitor cells

Shafiee, Abbas and Khosrotehrani, Kiarash (2016). Perinatal tissue-derived endothelial progenitor cells. In Babak Arjmand (Ed.), Perinatal tissue-derived stem cells: alternative sources of fetal stem cells (pp. 65-80) Cham, Switzerland: Springer International Publishing. doi:10.1007/978-3-319-46410-7_4

Author Shafiee, Abbas
Khosrotehrani, Kiarash
Title of chapter Perinatal tissue-derived endothelial progenitor cells
Title of book Perinatal tissue-derived stem cells: alternative sources of fetal stem cells
Place of Publication Cham, Switzerland
Publisher Springer International Publishing
Publication Year 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/978-3-319-46410-7_4
Open Access Status Not yet assessed
Year available 2016
Series Stem cell biology and regenerative medicine
ISBN 9783319464107
ISSN 2196-8985
Editor Babak Arjmand
Chapter number 4
Start page 65
End page 80
Total pages 16
Total chapters 11
Language eng
Abstract/Summary Endothelial progenitor cells (EPC) have been proposed as a cell population with de novo vessel formation potential for cardiovascular disease treatment, through improving neovascularization in ischemic tissues. Although initially the bone marrow was considered as the main source, EPC have been isolated from other tissues, including perinatal sources: umbilical cord blood and placenta. Perinatal EPC demonstrated similar phenotypic characteristics to other sources; however, they harbor advanced EPC quantity with improved proliferative potential. In vivo experiments also confirmed de novo vessel formation upon perinatal EPC transplantation and enhanced blood perfusion in engraftment areas. Altogether, the fetal EPC have been isolated and characterized from perinatal tissues with improved vascularization potential and at clinically relevant quantities. In this chapter, we will first review vascularization processes in the human placenta and then highlight strategies which have been conducted to harvest EPC from the human term placenta.
Keyword Endothelial Progenitor Cells
Stem cell
Q-Index Code B1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Book Chapter
Collections: HERDC Pre-Audit
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 04 Feb 2018, 11:16:43 EST