Draxin regulates hippocampal neurogenesis in the postnatal dentate gyrus by inhibiting DCC-induced apoptosis

Tawarayama, Hiroshi, Yamada, Hirohisa, Amin, Ruhul, Morita-Fujimura, Yuiko, Cooper, Helen M., Shinmyo, Yohei, Kawata, Masakado, Ikawa, Shuntaro and Tanaka, Hideaki (2018) Draxin regulates hippocampal neurogenesis in the postnatal dentate gyrus by inhibiting DCC-induced apoptosis. Scientific Reports, 8 1: 1-10. doi:10.1038/s41598-018-19346-6


Author Tawarayama, Hiroshi
Yamada, Hirohisa
Amin, Ruhul
Morita-Fujimura, Yuiko
Cooper, Helen M.
Shinmyo, Yohei
Kawata, Masakado
Ikawa, Shuntaro
Tanaka, Hideaki
Title Draxin regulates hippocampal neurogenesis in the postnatal dentate gyrus by inhibiting DCC-induced apoptosis
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2018-01-16
Year available 2018
Sub-type Article (original research)
DOI 10.1038/s41598-018-19346-6
Open Access Status DOI
Volume 8
Issue 1
Start page 1
End page 10
Total pages 10
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 1000 General
Abstract Hippocampal neurogenesis in the dentate gyrus (DG) is controlled by diffusible molecules that modulate neurogenic processes, including cell proliferation, differentiation and survival. To elucidate the mechanisms underlying hippocampal neurogenesis, we investigated the function of draxin, originally identified as a neural chemorepellent, in the regulation of neuronal survival in the DG. Draxin was expressed in Tbr2 (+) late progenitors and NeuroD1 (+) neuroblasts in the dentate granule cell lineage, whereas expression of its receptor DCC (deleted in colorectal cancer) was mainly detectable in neuroblasts. Our phenotypic analysis revealed that draxin deficiency led to enhanced apoptosis of DCC-expressing neuroblasts in the neurogenic areas. Furthermore, in vitro assays using a hippocampal neural stem/progenitor cell (HNSPC) line indicated that draxin inhibited apoptosis in differentiating HNSPCs, which express DCC. Taken together, we postulate that draxin plays a pivotal role in postnatal DG neurogenesis as a dependence receptor ligand for DCC to maintain and promote survival of neuroblasts.
Keyword Single-Stranded-Dna
Adult Neurogenesis
Axonal Outgrowth
Guidance Protein
Survival Factor
Cell-Survival
Receptor Dcc
Spinal-Cord
Stem-Cells
Migration
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 25870538
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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Created: Wed, 24 Jan 2018, 12:18:51 EST