Proteomic and functional variation within black snake venoms (Elapidae: Pseudechis)

Goldenberg, Jonathan, Cipriani, Vittoria, Jackson, Timothy N. W., Arbuckle, Kevin, Debono, Jordan, Dashevsky, Daniel, Panagides, Nadya, Ikonomopoulou, Maria P., Koludarov, Ivan, Li, Bin, Santana, Renan Castro, Nouwens, Amanda, Jones, Alun, Hay, Chris, Dunstan, Nathan, Allen, Luke, Bush, Brian, Miles, John J, Ge, Lilin, Kwok, Hang Fai and Fry, Bryan G (2018) Proteomic and functional variation within black snake venoms (Elapidae: Pseudechis). Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology, 205 53-61. doi:10.1016/j.cbpc.2018.01.001

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Author Goldenberg, Jonathan
Cipriani, Vittoria
Jackson, Timothy N. W.
Arbuckle, Kevin
Debono, Jordan
Dashevsky, Daniel
Panagides, Nadya
Ikonomopoulou, Maria P.
Koludarov, Ivan
Li, Bin
Santana, Renan Castro
Nouwens, Amanda
Jones, Alun
Hay, Chris
Dunstan, Nathan
Allen, Luke
Bush, Brian
Miles, John J
Ge, Lilin
Kwok, Hang Fai
Fry, Bryan G
Title Proteomic and functional variation within black snake venoms (Elapidae: Pseudechis)
Journal name Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology   Check publisher's open access policy
ISSN 1532-0456
Publication date 2018-02-01
Year available 2018
Sub-type Article (original research)
DOI 10.1016/j.cbpc.2018.01.001
Open Access Status File (Author Post-print)
Volume 205
Start page 53
End page 61
Total pages 9
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Abstract Pseudechis (black snakes) is an Australasian elapid snake genus that inhabits much of mainland Australia, with two representatives confined to Papua New Guinea. The present study is the first to analyse the venom of all 9 described Pseudechis species (plus one undescribed species) to investigate the evolution of venom composition and functional activity. Proteomic results demonstrated that the typical Pseudechis venom profile is dominated by phospholipase A2 toxins. Strong cytotoxicity was the dominant function for most species. P. porphyriacus, the most basal member of the genus, also exhibited the most divergent venom composition, being the only species with appreciable amounts of procoagulant toxins. The relatively high presence of factor Xa recovered in P. porphyriacus venom may be related to a predominantly amphibian diet. Results of this study provide important insights to guide future ecological and toxinological investigations.
Keyword Oxyuraninae
Black snakes
Venom evolution
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID MYRG2015-00025-FHS
Institutional Status UQ

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Created: Wed, 24 Jan 2018, 12:05:17 EST