Iris pigmented lesions as a marker of cutaneous melanoma risk: an Australian case-control study

Laino, A. M., Berry, E. G., Jagirdar, K., Lee, K. J., Duffy, D. L., Soyer, H. P. and Sturm, R. A. (2018) Iris pigmented lesions as a marker of cutaneous melanoma risk: an Australian case-control study. British Journal of Dermatology, . doi:10.1111/bjd.16323

Author Laino, A. M.
Berry, E. G.
Jagirdar, K.
Lee, K. J.
Duffy, D. L.
Soyer, H. P.
Sturm, R. A.
Title Iris pigmented lesions as a marker of cutaneous melanoma risk: an Australian case-control study
Journal name British Journal of Dermatology   Check publisher's open access policy
ISSN 1365-2133
Publication date 2018-01-08
Sub-type Article (original research)
DOI 10.1111/bjd.16323
Open Access Status Not yet assessed
Total pages 24
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Background: Iris naevi and iris freckles have a frequency of 4% and 50% in the European population. They are associated with dysplastic naevi, but few studies examine their link to cutaneous melanoma.

Objectives: To assess whether iris pigmented lesions are a predictive indicator for cutaneous melanoma.

Methods: This is a melanoma case-control study of 1254 European-background Australians. Sun exposure and melanoma history, a saliva sample for DNA analysis, and eye photographs taken with a digital camera were collected from 1117 participants. Iris images were assessed by up to four trained observers for the number of iris pigmented lesions. The data was analysed for correlations between iris pigmented lesions and melanoma history.

Results: Cases over the age of 40 had similar numbers of iris pigmented lesions to age matched controls (mean 5.7 vs 5.2, P=0.02), but younger cases and controls had a greater difference (mean 3.96 vs 2.19, P=0.004). A logistic regression adjusted for age, sex, skin, hair and eye colour, skin freckling and naevus count found that the presence of three or more iris pigmented lesions increases the melanoma risk 1.45-fold (CI 95% 1.07-1.95). HERC2/OCA2 rs12913832 and IRF4 rs12203592 influenced both eye colour and the number of iris pigmented lesions. On the HERC2/OCA2 A/A and A/G genotype background there was an increasing proportion of blue eye colour when carrying the IRF4 T allele (P=3x10-4) and a higher number of iris pigmented lesions with the IRF4 T/T homozygote (P=3x10-9).

Conclusions: Iris pigmented lesions count provides additional predictive information for melanoma risk above that from conventional risk factors.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: eSpace Followup
UQ Diamantina Institute Publications
Version Filter Type
Citation counts: Google Scholar Search Google Scholar
Created: Wed, 17 Jan 2018, 12:20:30 EST